Browsing National Centre for Biomedical Engineering Science by Author "Smith, Terry"
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Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2009-06-09)This study set out to investigate whether differential expression of genes for acute phase proteins in rainbow trout (Oncorhynchus mykiss) could be induced by confinement stress, a non-invasive method of activating the ... -
Analysis of Maxi-K alpha subunit splice variants in human myometrium
Curley, Michael; Morrison, John J.; Smith, Terry (springer, 2004-09-21)Background: Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the regulatory mechanism(s) governing ... -
Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family
Johnson, Mark C.; Sangrador-Vegas, Amaia; Smith, Terry; Cairns, Michael T. (Elsevier, 2006-04-15)To identify genes connected with leucocyte function in rainbow trout a cDNA library derived front head kidney leucocytes exposed to phytohemagglutinin (PHA) was screened. A clone with homology to the previously described ... -
Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy
Smith, Terry (2013)Background: Obesity is becoming an increasing problem in obstetric practice; it has led to an increase in the risk of caesarean delivery, prolonged pregnancy and dysfunctional labour. It has been postulated that many of ... -
Differential expression of the metalloproteinase MMP3 and the a5 integrin subunit in human myometrium at labour
Ahamide, Elodie; Morrison, John J.; O Shaughnessy, Deirdre; O Brien, Margaret; Smith, Terry (Oxford University Press, 2007-09-13)Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ... -
Effects of combined progesterone and beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
Chandran, Sreenath; Cairns, Michael T.; O Brien, Margaret; O Connell, Enda; Mashayekhi, Kaveh; Smith, Terry (American Physiological Society, 2015)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ... -
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells
Prasad, Babu R.; Mullins, Gillian; Nikolskaya, Natalia; Connolly, David; Smith, Terry; Rochev, Yury (BioMed Central, 2012-01-20)Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ... -
Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens
Maher, Majella; Glennon, Maura; Smith, Terry; Dawson, Michael T. (ACM, 1996-06-18)We report on a PCR-based assay we have developed for the detection of Mycobacterium tuberculosis in sputum samples. One hundred sputum specimens, which included 34 culture-positive and 66 culture-negative specimens, were ... -
Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs.
Wernecke, Martina; Mullen, Ciara; Sharma, Vimla; Morrison, John; Barry, Thomas; Maher, Majella; Smith, Terry (2009)Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. Strategies to identify women who are at risk of transmitting ... -
Expression of RHOGTPase regulators in human myometrium
Mullins, Brian; O'Brien, Margaret; Flynn, David; Smith, Terry; Morrison, John J. (Reproductive Biology and Endocrinology, 2008-01-11)Background: RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), ... -
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry; Morrison, John J. (Endocrine Society, 2005-07-02)Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ... -
Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models
McInerney, James O; Smith, Terry; Mahony, Shaun; Golden, Aaron (BioMed Central, 2005-03-05)Background: Many current gene prediction methods use only one model to represent protein-coding regions in a genome, and so are less likely to predict the location of genes that have an atypical sequence composition. It ... -
Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models
Mahony, Sean; Smith, Terry (2004-03-05)This work explores a new approach to gene-prediction, based on the Self-Organizing Map, which has the ability to automatically identify multiple gene models within a genome. The current implementation, named RescueNet, ... -
Ghrelin in the human myometrium
O'Brien, Margaret; Earley, Padraig; Morrison, John J.; Smith, Terry (BioMed Central Ltd, 2010-03-29)Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ... -
Ghrelin in the human myometrium
Smith, Terry; O'Brien, Margaret; Morrison, John J. (2010)Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ... -
Global gene expression analysis of the effects of Vinblastine on endothelial cells, when eluted from a thermo-responsive polymer
McLucas, Emily; Rochev, Yury; Carroll, W. M.; Smith, Terry (Wiley Online Library, 2006-06-30)In-stent restenosis remains a significant problem associated with bare metal stents. This drawback has prompted research into improving stent design and the development of novel coatings, including drug-eluting stents. A ... -
Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use
Prasad, Babu R.; Nikolskaya, Natalia; Connolly, David; Smith, Terry; Rochev, Yury (2010)Background: The unique and tuneable photonic properties of Quantum Dots (QDs) have made them potentially useful tools for imaging biological entities. However, QDs though attractive diagnostic and therapeutic tools, have ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Morrison, John J.; Smith, Terry; O'Brien, Margaret; Fitzgibbon, Joan (Springer, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Fitzgibbon, Joan; Morrison, John J.; Smith, Terry; O'Brien, Margaret (BioMed Central, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ...