Browsing National Centre for Biomedical Engineering Science by Author "Morrison, John J."
Now showing items 1-11 of 11
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Analysis of Maxi-K alpha subunit splice variants in human myometrium
Curley, Michael; Morrison, John J.; Smith, Terry (springer, 2004-09-21)Background: Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the regulatory mechanism(s) governing ... -
Differential expression of the metalloproteinase MMP3 and the a5 integrin subunit in human myometrium at labour
Ahamide, Elodie; Morrison, John J.; O Shaughnessy, Deirdre; O Brien, Margaret; Smith, Terry (Oxford University Press, 2007-09-13)Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ... -
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Maharaj, Chrisen H.; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D.; Morrison, John J.; Laffey, John G. (2009)Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ... -
Expression of RHOGTPase regulators in human myometrium
Mullins, Brian; O'Brien, Margaret; Flynn, David; Smith, Terry; Morrison, John J. (Reproductive Biology and Endocrinology, 2008-01-11)Background: RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), ... -
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry; Morrison, John J. (Endocrine Society, 2005-07-02)Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ... -
Ghrelin in the human myometrium
O'Brien, Margaret; Earley, Padraig; Morrison, John J.; Smith, Terry (BioMed Central Ltd, 2010-03-29)Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ... -
Ghrelin in the human myometrium
Smith, Terry; O'Brien, Margaret; Morrison, John J. (2010)Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Morrison, John J.; Smith, Terry; O'Brien, Margaret; Fitzgibbon, Joan (Springer, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Fitzgibbon, Joan; Morrison, John J.; Smith, Terry; O'Brien, Margaret (BioMed Central, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ... -
Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction
Friel, Anne M,; Sexton, Donal J.; O'Reilly, Michael W.; Smith, Terry; Morrison, John J. (Society for Reproduction and Fertility, 2006-07-01)Pre eclampsia represents a state of increased or prolonged vasoconstriction, partially linked to the potent vasocontractile effect of isoprostanes. The process of Rho A-mediated calcium sensitisation is inherent to a state ... -
Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor.
O'Brien, Margaret; Morrison, John J.; Smith, Terry (Sage, 2008)The regulatory mechanisms underlying myometrial smooth muscle contractility during labor are poorly understood. The authors therefore investigated the transcriptional profile of the changes that occur in the human myometrium ...