Browsing Research Institutes and Centres by Subject "Gene therapy"

Now showing items 1-6 of 6

    • Future directions in managing aniridia-associated keratopathy 

      van Velthoven, Arianne J.H.; Utheim, Tor P.; Notara, Maria; Bremond-Gignac, Dominique; Figueiredo, Francisco C.; Skottman, Heli; Aberdam, Daniel; Daniels, Julie T.; Ferrari, Giulio; Grupcheva, Christina; Koppen, Carina; Parekh, Mohit; Ritter, Thomas; Romano, Vito; Ferrari, Stefano; Cursiefen, Claus; Lagali, Neil; LaPointe, Vanessa L.S.; Dickman, Mor M. (Elsevier, 2023-05-04)
      Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of ...

    • Gene therapy in transplantation: Toward clinical trials 

      Ritter, Thomas (Thompson, 2009)
      The genetic modification of organs or cells is an attractive approach to protect allogeneic transplants from acute rejection and other complications. The transplant setting offers a unique opportunity to utilise ex vivo ...

    • Immunogenicity of allogeneic mesenchymal stem cells 

      Ritter, Thomas (2012)
      Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ...

    • An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia 

      Dash, Biraja C.; Thomas, Dilip; Monaghan, Michael; Carroll, Oliver; Chen, Xizhe; Woodhouse, Kimberly; O'Brien, Timothy; Pandit, Abhay (Elsevier, 2015-10)
      Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ...

    • Non-viral gene therapy for myocardial engineering 

      Holladay, Carolyn A.; O'Brien, Timothy; Pandit, Abhay (John Wiley & Sons, Ltd., 2010-05)
      Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ...

    • Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro 

      McMahon, Siobhan; Nikolskaya, Natalia; Ní Choileain, Siobhan; Hennessy, Niamh; O'Brien, Timothy; Rochev, Yury (Wiley, 2011-11-01)
      Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried ...