Browsing College of Engineering and Informatics by Subject "Bone"
Now showing items 1-8 of 8
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Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
(2013)The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ... -
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
(Springer Verlag, 2013-04-09)Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
(Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
(AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ... -
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
(The Royal Society Publishing, 2012-06-06)The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ... -
A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone
(Elsevier, 2012-03-20)Bone is an exceptional material that is lightweight for efficient movement but also exhibits excellent strength and stiffness imparted by a composite material of organic proteins and mineral crystals that are intricately ...