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Revealing the Origin and Nature of Drug Resistance of Dynamic Tumour Systems

ARAN - Access to Research at NUI Galway

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dc.contributor.author Santiago-Mozos, Ricardo en
dc.contributor.author Khan, Imtiaz A. en
dc.contributor.author Madden, Michael G. en
dc.date.accessioned 2011-01-21T16:36:28Z en
dc.date.available 2011-01-21T16:36:28Z en
dc.date.issued 2010 en
dc.identifier.citation Santiago-Mozos, R.; Khan, I.A.; Madden M. G. (2010) 'Revealing the Origin and Nature of Drug Resistance of Dynamic Tumour Systems'International Journal of Knowledge Discovery in Bioinformatics, 1(4), 26-53, 2010 en
dc.identifier.uri http://hdl.handle.net/10379/1562 en
dc.description.abstract In this paper, the authors identify the strategies that resistant subpopulations of cancer cells undertake to overcome the effect of the anticancer drug Topotecan. For the analyses of cell lineage data encoded from timelapse microscopy, data mining tools are chosen that generate interpretable models of the data, addressing their statistical significance. By interpreting the short-term and long-term cytotoxic effect of Topotecan through these data models, the authors reveal the strategies that resistant subpopulations of cells undertake to maximize their clonal expansion potential. In this context, this paper identifes a pattern of cell death independent of cytotoxic effect. Finally, it is observed that cells exposed to Topotecan have higher movement over time, indicating a putative relationship between cytotoxic effect and cell motility. en
dc.format application/pdf en
dc.language.iso en en
dc.subject Cancer en
dc.subject Cell lineage en
dc.subject Data mining en
dc.subject Drug resistance en
dc.subject Oncology en
dc.subject Osteosarcoma en
dc.subject Topotecan en
dc.title Revealing the Origin and Nature of Drug Resistance of Dynamic Tumour Systems en
dc.type Article en
dc.local.publishedsource http://dx.doi.org/10.4018/jkdb.2010100102 en
dc.local.publisherstatement This chapter/paper appears in International Journal of Knowledge Discovery in Bioinformatics, edited by Xiao-Li Li & See-Kiong Ng Copyright 2010, IGI Global, www.igi-global.com. Posted by permission of the publisher. en
dc.description.peer-reviewed peer-reviewed en
dc.contributor.funder FP6 en
dc.contributor.funder Fundación Española para la Ciencia y la Tecnología en

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