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Atypical behavioural effects of lorazepam: Clues to the design of novel therapies?

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dc.contributor.author Elliott, Mark en
dc.date.accessioned 2011-01-11T16:03:09Z en
dc.date.available 2011-01-11T16:03:09Z en
dc.date.issued 2010-04 en
dc.identifier.citation Giersch, A., Boucart, M., Elliott, M., & Vidailhet, P. Atypical behavioural effects of lorazepam: Clues to the design of novel therapies? Pharmacology & Therapeutics, 126(1), 94-108. en
dc.identifier.issn 0163-7258 en
dc.identifier.uri http://hdl.handle.net/10379/1535 en
dc.description.abstract Aside from their pharmacokinetic properties, e.g. their speed of action and the duration of residual effects, benzodiazepines are still considered as equivalent in terms of their effects on cognition. Here we review evidence suggesting that certain benzodiazepines, especially lorazepam, differ in a number of respects, in particular with respect to their effects on cognition. We focus this review on memory, attention and visual perception, where impairments may be brought about by only a subset of benzodiazepines in spite of their administration at doses inducing similar sedative effects. This precludes an explanation in terms of sedation. Differences in the effects of benzodiazepines have also been found in electrophysiological and animal behavioural studies. These studies are important for therapeutic approaches for two reasons: first, effects of benzodiazepine prescription on cognitive functions will differ according to the benzodiazepine, contrary to what is usually believed. Less straightforwardly are the possible therapeutic implications of specific effects on cognition following treatment with lorazepam. Indeed, the specific effects this drug has on cognition may reveal not only side-effects but also effects of potential therapeutic value. Current research concentrates on a fine scale analysis of the effects of GABA on different sub-types of GABAA receptors. We suggest that from looking at what makes lorazepam different in a behavioural sense from other benzodiazepines we may be in a position to design innovative treatments for major aspects of complex disorders, including schizophrenia. en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.subject Psychology en
dc.subject Benzodiazepines en
dc.subject Lorazepam en
dc.subject GABA en
dc.subject Perception en
dc.subject Memory en
dc.subject Imaging en
dc.subject Cognition en
dc.title Atypical behavioural effects of lorazepam: Clues to the design of novel therapies? en
dc.type Article en
dc.local.publishedsource http://dx.doi.org/10.1016/j.pharmthera.2010.01.004 en
dc.description.peer-reviewed peer-reviewed en

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