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Enhanced GABA-A inhibition enhances synchrony coding in human perception

ARAN - Access to Research at NUI Galway

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dc.contributor.author Elliott, Mark en
dc.date.accessioned 2010-11-26T16:02:36Z en
dc.date.available 2010-11-26T16:02:36Z en
dc.date.issued 2000-10-20 en
dc.identifier.citation Elliott, M. A., Becker, C., Boucart, Mueller, H. J. (2000). Enhanced GABAA inhibition enhances synchrony coding in human perception. NeuroReport, 11(15), 3403-3407. en
dc.identifier.issn 0959-4965 en
dc.identifier.uri http://hdl.handle.net/10379/1462 en
dc.description.abstract The benzodiazepine, lorazepam enhances the efficiency of local, inhibitory GABAA synapses in the cortex, which stabilize postsynaptic, excitatory activity by synchronizing their own discharges at around 40 Hz. Treatment with lorazepam has also been shown to adversely influence detection performance in perceptual tasks, suggesting a role for GABAA-mediated synchronization during visuo-perceptual organization. Consistent with these findings we report that reaction times to target stimuli were slower following lorazepam treatment. However, when targets followed presentation of a synchronized prime, presented within a flickering 40-Hz display matrix, the effects of priming were amplified relative to baseline and control conditions. We conclude that enhanced GABAA-induced inhibition enhances stimulus-evoked synchronization with differential effects upon mechanisms of perceptual segmentation and grouping. en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Lippincott Williams & Wilkins en
dc.subject Psychology en
dc.subject 40 Hz en
dc.subject Benzodiazepine en
dc.subject GABAA en
dc.subject Grouping en
dc.subject Lorazepam en
dc.subject Priming en
dc.subject Segmentation en
dc.subject Synchronization en
dc.subject Vision en
dc.title Enhanced GABA-A inhibition enhances synchrony coding in human perception en
dc.type Article en
dc.local.publishedsource http://journals.lww.com/neuroreport/Fulltext/2000/10200/Enhanced_GABAA_inhibition_enhances_synchrony.27.aspx en
dc.description.peer-reviewed peer-reviewed en
dc.contributor.funder Deutsche Forschungsgemeinschaft project grant SCHR 375/8-1 en
dc.contributor.funder EEC Biomed 2 project grant en

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