Browsing University of Galway Theses (PhD Theses) by Author "Rochev, Yury"
Now showing items 1-11 of 11
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Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
Kotla, Niranjan (NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
Characterisation of bovine pericardium and alternative treatments for its application as biomaterial
Joyce, Karl (NUI Galway, 2020-04-09)Bovine pericardium is an extensively used biomaterial utilised in a wide range of biomedical devices such as bioprosthetic heart valves. The characterisation techniques employed for the analysis of bovine pericardium and ... -
Development of Simplified NIPAm-based Thermoresponsive Films for Cell Preservation, Expansion and Differentiation
Fan, Xingliang (2013-12-16)Traditional cell recovery methodologies cleave cell-to-cell junctions and thus the recovery of an intact cell sheet for use in tissue engineering is rendered impossible. Additionally, these traditional cell detachment ... -
Experimental and computational analysis of the mechanical behavior of poly(lactic-co-glycolic acid) during degradation for medical implant applications
Neghabat Shirazi, Reyhaneh (2016-01-25)Biodegradable polymers such as PLGA have been used in a wide range of biomedical applications due to their hydrolytic degradation and biocompatibility. The mechanical performance of biodegradable polymers during degradation ... -
In-vitro cellular interaction of quantum dots and silicone surfaces
Bodi, Babu Rajendra Prasad (2011-09-30)The main hypothesis on which this study has been based is that the surface modification of nano-particles of different size (Quantum Dots) and varying nano-surfaces roughness (Silicones of nanosurface roughness) can make ... -
Integrating the old and new: smart thermoresponsive surfaces and 3D fabrication technologies for tissue engineering
Dzhoyashvili, Nina (2017-05-08)One promising direction of regenerative medicine is the development of cell sheet-based tissue-like constructs. The cell sheets preserve ECM and cell−cell junctions. This may greatly support cell adherence to damaged organ ... -
Molecular Beacons for Tissue Engineering Applications
Alexander, Jennifer (2012-09-28)A complete spatiotemporal profile of the mechanisms involved in the synthesis, processing, and transport of RNA will improve our understanding of cell function and behaviour under various biological cues, which could ... -
Quantum dots in bio-imaging and drug delivery
Gladkovskaya, Olga (2015-11-23)This work explores a range of bionanomaterials, with particular attention to their influence on cell growth, function and fate. Also the issue of intracellular nanoparticles quantification has been addressed in experimental ... -
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
Alzahrani, Abdullah (NUI Galway, 2018-10-15)Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ... -
Smart biomaterials for cell sheet engineering
Healy, Deirdre (2016-03-23)The aim of this instigation was to develop thermoresponsive polymer films for cell culture use. Conventional cell detachment methods involve the use of proteolytic enzymes, such as trypsin, or mechanical scrapping. These ... -
A source of new diagnostic techniques for asthma in Ireland
Hutchinson, Ekaterina (2017-11-13)The objective of this thesis is to set up new diagnostic methods for the study of asthma and related respiratory conditions in an Irish clinical laboratory, and to deepen our knowledge of the pathophysiology of this illness. ...