Browsing University of Galway Theses (PhD Theses) by Author "Roche, Michelle"
Now showing items 1-13 of 13
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Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
Burke, Nikita (2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Endocannabinoid modulation of TLR3-induced neuroinflammation
Flannery, Lisa (2017-10-06)Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ... -
Endocannabinoid modulation of TLR4-induced neuroinflammation: implications for autism spectrum disorders
Kerr, Daniel Martin (2014-07-07)Neuroinflammation is a key component of various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis and psychiatric and neurodevelopmental disorders such as depression and autism. ... -
Endocannabinoid regulation of neuroinflammatory responses following acute systemic viral (TLR3) and bacterial (TLR4) infection
Henry, Rebecca Jane (2015-10-14)Toll like receptors (TLRs) are key players in host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation has been proposed to trigger the onset of certain neurodegenerative disorders ... -
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
McHugh, Kelly Louise (NUI Galway, 2020-02-27)In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ... -
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
Madasu, Manish Kumar (2016-09-21)The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ... -
Interferon alpha-induced changes in emotional and nociceptive processing: involvement of the endocannabinoid system
Fitzgibbon, Marie (2015-11-13)Interferon-α (IFN-α) is a pro-inflammatory cytokine used for the treatment of hepatitis B and C as well as various malignancies. However, therapy is often associated with neuropsychiatric side effects, including depression ... -
Novel approaches to the understanding and treatment of postoperative pain
Power, Emer (NUI Galway, 2019-12-06)Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ... -
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
Jarrin, Sarah (NUI Galway, 2019-11-15)Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ... -
The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
Thornton, Aoife M. (NUI Galway, 2020-10-20)Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ... -
The role of the endocannabinoid system in the emotional modulation of pain
Corcoran, Louise (NUI Galway, 2018-09-06)Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ... -
The role of the endogenous opioid system in hyperalgesia associated with negative affect
Ferdousi, Mehnaz (NUI Galway, 2020-02-26)Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ... -
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
Hughes, Edel M. (NUI Galway, 2019-11-11)Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ...