Browsing University of Galway Theses (PhD Theses) by Author "Pandit, Abhay"
Now showing items 1-20 of 27
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Anti-Inflammatory Gene Therapy for the Promotion of Implanted Stem Cell Survival in Infarcted Myocardium
Holladay, Carolyn (2011-04-13)Cardiovascular disease is the leading cause of death in the developed world and is responsible for approximately 36% of Irish mortality. Myocardial infarction (MI), which is literally the death of cardiac tissue due to ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
Mathew, Asha (2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
Kotla, Niranjan (NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
A biomaterials approach to peripheral nerve repair
Daly, William (2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
Doody, Jaime (NUI Galway, 2016-02-15)Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ... -
Developing reservoir systems for therapeutic delivery of biomolecules to a degenerated disc
Fontana, Gianluca (2015-01-05)Low back pain has severe consequences for the quality of life of the affected patients and strong evidence suggests that this condition is caused by degeneration of the intervertebral disc (IVD). Disc degeneration coincides ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
Thomas, Dilip (2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Development of a mixed glial in vitro robust platform for therapeutic applications in spinal cord injury
Patil, Vaibhav (NUI Galway, 2021-06-30)Spinal cord injury (SCI) is a catastrophic event, and current strategies for SCI pose several limitations. One of the critical hallmarks of SCI is inflammation, which is due to the activation of microglia and astrocytes. ... -
Elastin-based hydrogel as a treatment for critical limb ischemia, an insight into the glyco-host response
Marsico, Grazia (NUI Galway, 2019-10-01)Critical limb ischemia (CLI) is severe impairment of the microcirculation resulting in inflammation, ischaemic pain, non-healing ulcers and gangrene. Over 20% of patients have no option but to undergo a major limb amputation. ... -
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
Dash, Biraja (2014-12-17)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ... -
Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction
Contessotto, Paolo (NUI Galway, 2019-04-17)Myocardial infarction (MI) belongs to the family of cardiovascular diseases and represents the primary cause of worldwide mortality. Despite the promising results achieved in both small and large animal studies, recent ... -
Fibrin Mediated Proangiogenic and Secretory Control Gene Therapy for Compromised Wound Healing
Kulkarni, Mangesh (2012-07-18)Chronic or compromised healing is a major clinical problem. Particularly, in diabetes where the disease process hinders the capacity to repair the tissue damage, the patients are more susceptible to chronic ulcers, especially ... -
Fibrin-in-fibrin intervention for enhanced dopaminergic graft survival in Parkinson’s disease: Special focus on brain N-glycans
Samal, Juhi (NUI Galway, 2019-11-07)Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder caused due to the selective loss of dopaminergic neurons in substantia nigra pars compacta (SN) translating into the classical motor symptoms ... -
A glyco approach for the treatment of Parkinson’s disease: From the glycobiological characterisation to the development of glyco-modulatory collagen-based hydrogel systems
Rebelo, Ana Lúcia (NUI Galway, 2021-12-20)Parkinson’s disease (PD) is the most common motor-related progressive neurodegenerative condition, mainly caused by the loss of dopaminergic neurons in the substantia nigra. Despite the increased knowledge regarding its ... -
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
Ronan, Rachel (NUI Galway, 2020-02-04)Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ... -
An injectable collagen scaffold delivering exogenous microRNA as a therapy to modulate extracellular matrix remodelling
Monaghan, Michael (2013-06-01)Cardiovascular disease is the leading cause of death in the developed world and is responsible for approximately 36% of Irish mortality. Myocardial infarction (MI), which is literally the death of cardiac tissue due to ... -
Integrated proteomic and systems biology approach to understanding injured spinal cord pathophysiology and repair
Kshirsagar, Aniket (NUI Galway, 2020-03-05)Spinal cord injury (SCI) is a severe neurological condition. There are currently no effective treatment options to restore function following SCI. The major obstacle to developing effective therapies is the fragmented ... -
Investigating the effect of anti-inflammatory hyaluronic acid towards regenerating the annulus fibrosus
Kazezian, Zepur (2017-05-11)Neck and low-back pain are major causes of disability leading to a serious socio-economic burden worldwide. The pathology is strongly correlated with the intervertebral disc degeneration (IVD). Disc degenerative disease ... -
Investigating the roles of MARCKS and MARCKS-like 1 proteins in Xenopus laevis spinal cord development and regeneration
El Amri, Mohamed (NUI Galway, 2024-02-12)The identification and characterisation of key molecules that can promote or suppress regeneration has been an elusive, long-sought objective for researchers in spinal cord injury. The myristoylated alanine-rich C-kinase ... -
Molecular Beacons for Tissue Engineering Applications
Alexander, Jennifer (2012-09-28)A complete spatiotemporal profile of the mechanisms involved in the synthesis, processing, and transport of RNA will improve our understanding of cell function and behaviour under various biological cues, which could ...