Browsing University of Galway Theses (PhD Theses) by Subject "National Centre for Biomedical Engineering Science"
Now showing items 1-5 of 5
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Development and characterisation of recognition molecules for the specific identification of non-human glycans
(2015-01-26)Glycosylation is an enzymatic process through which glycans attach to proteins, lipids and other organic molecules with huge structural diversity. This is a common post-translational modification found on proteins and cell ... -
Examining a new class of dual CDC7/CDK9 inhibitors, mechanisms of proliferation, and proliferation-based stratification in myeloma
(2014-09-05)A key feature of progressive myeloma is a relative increase in proliferation. The DBF4-dependent kinase (DDK), cell division cycle 7 (CDC7), is an essential kinase for initiation of DNA replication. This thesis assesses ... -
Intra-Renal Inflammation in Obesity and Type 2 Diabetes Mellitus
(2013-09-30)Introduction: Unhealthy diet and sedentary lifestyle, lead to the constellation of obesity, hyperinsulinaemia and hyperlipidaemia that are risk factors for both chronic kidney disease and type 2 Diabetes mellitus. Renal ... -
Non-invasive time sampled venous pressure detection for research and clinical applications
(2014-09)The venous system of the lower limbs has unique anatomy that provides a skeletal muscle pump for the transport of blood against the hydrostatic gradient of erect postures. This muscle pump enables the regulation of venous ... -
Regulation Of Myometrial Gene Expression By Oestrogen And Progesterone: The Use Of A Cell Culture Model To Mimic The In Vivo Conditions Of Pregnant Human Uterus
(2012-12-31)Pregnancy and labour are physiological events controlled by a complex interplay between maternal and foetal factors. These processes are diverse and specific to each species, hence simple extrapolation from model organisms ...