Browsing University of Galway Theses (PhD Theses) by Author "Kelly, John"
Now showing items 1-6 of 6
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Development and characterisation of a novel preclinical test battery for detecting anxiolytic and antidepressant properties of drugs
Bannerton, Karen (2016-10-19)Depression is a chronic, recurring and potentially life-threatening disorder that is highly comorbid with anxiety. The aetiology of depression, anxiety and their comorbidity is still largely unknown. Despite the development ... -
The Influence of Housing, Sex and Strain on Baseline and Drug-Induced Behavioural and Neurochemical Parameters in the Rat
Simpson, Joy (2011-09-30)A number of confounding factors are believed to affect both basal rodent behaviour and responsivity to psychotropic drugs. To date, few detailed comparative assessments of these confounds have been made. This thesis examined ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
McAleavey, Zara (2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
Modelling early life exposure to antidepressants in rats: Developmental, behavioural and neurochemical aspects
O'Brien, Sandra (2013-02-11)Depression during pregnancy and the postpartum period has been associated with deleterious consequences such as preterm birth, low birth weight and less optimal scores on neonatal reflexes and behaviour. Pharmacological ... -
Novel approaches to the understanding and treatment of postoperative pain
Power, Emer (NUI Galway, 2019-12-06)Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ... -
The role of the endogenous opioid system in hyperalgesia associated with negative affect
Ferdousi, Mehnaz (NUI Galway, 2020-02-26)Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...