Browsing University of Galway Theses (PhD Theses) by Subject "DT40"
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Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability
(2011-06)Nse2/ Mms21 is an E3 SUMO ligase component of the Smc5/6 complex, which plays multiple roles in maintaining genome stability. To study the functions of the vertebrate Nse2 orthologue, we generated Nse2-deficient chicken ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
(2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ...