Browsing University of Galway Theses (PhD Theses) by Subject "Chromosome Biology"
Now showing items 1-5 of 5
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Centrosome cohesion: functions of C-NAP1
(2016-01-07)Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next. Detection of lesions ... -
Organisation and function of the Nucleolar Organiser Regions in human chromosomes.
(2013-12-20)The short-arms of the five acrocentric human chromosomes contain sequences that direct the assembly and function of the nucleolus, one of the key functional domains of the nucleus and ribosomal biogenesis, yet they are ... -
Reverse Genetic Analysis of Pericentrin Functions
(2012-06-11)The centrosome is a subcellular organelle that organises the mitotic spindle microtubules to ensure accurate segregation of chromosomes during cell division. Most animal centrosomes comprise a pair of centrioles which are ... -
Role of Rad9 cell cycle phosphorylation in the regulation of Chk1 activation
(2012-01-07)DNA damage checkpoints are triggered in response to DNA insults. Once activated, these pathways prevent replication and segregation of the damaged DNA. In addition to cell cycle delays they regulate repair, transcription ... -
Upstream Binding Factor, an Evolutionarily Conserved Protein that Organises Ribosomal Gene Chromatin
(2012-09-28)The nucleolus, the site of ribosome biogenesis, forms around arrays of ribosomal gene (rDNA) repeats termed nucleolar organiser regions (NORs). Transcriptionally active NORs appear as regions of under-condensed chromatin ...