Browsing University of Galway Theses (PhD Theses) by Author "Ceredig, Rhodri"
Now showing items 1-9 of 9
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Bone marrow stromal cell transplantation ameliorates cytopenias caused by depletion of FAP-α expressing cells
Camarillo Retamosa, Eva (NUI Galway, 2018-05-03)Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ... -
Characterization of post-traumatic immunosuppression and its partial reversal by autologous salvaged blood transfusion
Islam, Nahidul (2015-01-28)Documentary evidence of post-traumatic immunosuppression (PTI) is traceable back to 1856. Although improved hygiene has ameliorated many risks, vulnerability to systemic infection following major surgery or closed injury ... -
Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
Calvo Asensio, Irene (2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Investigation of intron coevolution and the autoimmune potential of alternative splicing
Keane, Peter (2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
An investigation of the immunometabolic interactions of obesity
Dennedy, Michael Conall (2013-09-04)Human monocytes are classified as classical, intermediate and non-classical according to their surface expression of CD14 and CD16. They also represent precursors to atherogenic foam cells and macrophages in metabolically ... -
Mesenchymal stromal cells: their immunosuppressive capacity and protein production profile
Ribeiro, Andreia (2016-08)The clinical benefits of mesenchymal stromal cell (MSC) based therapies for immune disorders and degenerative diseases are based on their combined ability to modulate the immune system and to differentiate into different ... -
Phenotypic and functional heterogeneity of intermediate monocytes in healthy adults.
Connaughton, Eanna (2015-09-30)Human blood monocytes are currently classified into three subsets: CD14++CD16- “Classical”, CD14++CD16+ “Intermediate” and CD14+CD16++ “Non-Classical”. Distinct functional differences between Classical and Non-Classical ... -
Prospective isolation and characterisation of mouse bone marrow-derived mesenchymal stromal cells
Baustian, Claas (2014-11-30)Conventionally cultured mouse bone marrow (mBM) mesenchymal stromal cells (MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, culture ... -
The response of mouse mesenchymal stromal cells to radiation-induced DNA double-strand breaks
Sugrue, Tara Kimberly (2013-12-16)Mesenchymal stromal cells (MSCs) are radio-resistant stem cell progenitors that support haematopoiesis in the bone marrow and contribute to the tumour microenvironment. The mechanisms that drive MSC radio-resistance are ...