Browsing University of Galway Theses (PhD Theses) by Subject "Cancer"
Now showing items 1-15 of 15
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Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
Computational approaches to identify and explain sources of error in cancer somatic mutation data
(NUI Galway, 2024-04-18)Errors in the identification of somatic mutations in cancer samples can have critical implications in both research and clinical applications. Failure to detect potential variants of interest can lead to missed opportunities ... -
Decoy Receptors block tumour cell eradication by TRAIL - Molecular engineering of TRAIL to evade decoy receptors
(2012-06-29)Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine expressed by immune cells which selectively eradicates a wide range of cancer cells while leaving normal healthy cells unharmed. TRAIL binds ... -
The development of an online intervention for post-treatment cancer survivors with cancer-related fatigue
(2017-02-02)Background The number of post-treatment cancer survivors in Ireland is set to increase in coming years, due to advances in screening and treatment. This group will require ongoing supportive care as many will experience ... -
An epigenomics approach to characterize alterations in disease
(NUI Galway, 2023-01-13)Epigenetics is the term that describes all the mechanisms that regulate the genomic activities such as transcription, DNA repair, DNA replication, transposon duplication. There is a great variety of epigenetic mechanisms ... -
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
(2016-11-30)Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ... -
hMOF and associated proteins in transcription and cancer
(2013-04-24)The lysine acetyltransferase MOF (males absent on the first) has been associated with transcriptional activation in Drosophila melanogaster. This activation is mediated by its acetylation of histone H4 at lysine 16 ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Mechanisms of bone marrow-mediated drug resistance in acute myeloid leukaemia
(NUI Galway, 2020-06-12)Acute myeloid leukaemia (AML) is a heterogenous clonal disorder characterised by the accumulation of immature, non-functional and highly proliferative blasts in the bone marrow and periphery. AML has a high relapse rate, ... -
Multimodal gold nanoprobes for optical imaging and therapy of cancer
(2016-05-20)In the recent past, there has been an accelerated development in medical modalities for the early diagnosis and treatment of cancer. Tissue conservation of neighbouring healthy tissue and development of a minimally/non-invasive ... -
Preclinical assessment of the novel compound EL102 in prostate cancer
(2015-03-31)Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ... -
The prognostic and therapeutic value of XBP1 signalling in ER-positive breast cancer
(NUI Galway, 2021-04-02)Breast cancer is a heterogeneous disease with distinct subtypes having specific molecular features. Approximately, 75% of breast cancers are estrogen receptor α (ER)-positive. Endocrine therapies have been used as a standard ... -
The role of IRE1α in the regulation of cytokine production
(NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ... -
A synthesis of systems engineering tools to improve patient safety, quality and efficiency in health care
(NUI Galway, 2021-04-13)Cancer occurrence has given rise to high risks and deaths of patients all over the world. The consistent negative impact of cancer on humans have spurred healthcare providers and administrators to judiciously search for ... -
Understanding adolescent adjustment to maternal cancer: a study of personal experiences and psychosocial factors that promote adjustment
(2016-01-05)Parental cancer is a stressful situation that can have a strong impact on adolescents lives (Su & Ryan-Wenger, 2007; Giesbers et al., 2010; Sieh et al., 2010; Helseth & Ulfsaet, 2003). Objectives The objectives of this ...