Browsing University of Galway Theses (PhD Theses) by Subject "Anomerisation"
Now showing items 1-7 of 7
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The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
(2015-04-29)There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ... -
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ... -
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ... -
A study of factors influencing anomerisation reactions
(2016-07-18)This thesis involves an investigation into the anomerisation reaction and strategies by which the reaction can potentially be improved and provide a greater understanding of factors influencing the reaction. There has been ... -
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ... -
Synthesis of novel glycolipids and investigation into the anomerisation of selenium glycosides
(2016-07-14)The first section of this thesis describes the synthesis of novel glycosphingolipids with an α-triazole at the anomeric carbon. Glycosphingolipids are amphiphilic molecules containing a carbohydrate head glycosidically ... -
Synthesis of S-glycolipids and peptidomimetics
(2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...