Browsing University of Galway Theses (PhD Theses) by Subject "DNA replication stress"
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CDC7 kinase regulates DNA replication fork processing and its inhibition is modulated by PTBP1
(NUI Galway, 2022-09-21)CDC7 is an essential serine/threonine kinase that regulates the initiation of DNA replication by phosphorylating several sites of the MCM helicase complex. Several inhibitors of CDC7 are available that reduce cell proliferation ...