Browsing University of Galway Theses (PhD Theses) by Subject "DNA methylation"
Now showing items 1-3 of 3
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Analysis and interpretation of epigenomic patterns in colonic epithelia
(2015-12-18)The methylation of cytosine nucleotides at the 5' position of DNA is a crucial epigenetic mechanism for the control of gene expression. Epigenome-wide associated studies have demonstrated that specific methylome patterns ... -
DNA methylation and zygotic genome activation during early embryogenesis of animals
(NUI Galway, 2020-10-25)Upon fertilization, after the fusion of two pronuclei, the newly formed zygotic genome is transcriptionally inactive. Hence, early animal development is driven by maternal RNAs and proteins. The zygotic genome becomes ... -
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...