Browsing University of Galway Theses (PhD Theses) by Author "Dowd, Eilís"
Now showing items 1-8 of 8
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Anti-inflammatory hydrogel enrichment for cell-based brain repair in Parkinson's disease
Cabré Giménez, Sílvia (NUI Galway, 2020-01-28)Cell transplantation as a therapeutic approach for Parkinson’s disease has been extensively studied over the past decades. The transplantation of primary dopaminergic neurons in the degenerated striatum has shown that these ... -
The cannabinoid type-2 (CB2) receptor as a target for anti-inflammatory disease modification in Parkinson's disease
Concannon, Ruth M. (2016-08-04)Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ... -
Development and characterisation of novel gene-environment interaction rat models of Parkinson's disease
Naughton, Carol (2016-08-04)Despite its discovery almost 60 years ago, levodopa remains the most effective therapy for the treatment of the motor symptoms associated with Parkinson’s disease. However, chronic use of levodopa is associated with serious ... -
Development of a dual-hit model of Parkinson's disease by combining environmental and genetic risk factors
Mulcahy, Pádraig John (2012-06-06)Even though half a century has passed since the discovery of the efficacy of the dopamine precursor, levodopa, it remains the most effective therapy for the motor symptoms of Parkinson's disease to this day, despite its ... -
Inflammatory-environment interactions as an approach to modelling Parkinson's disease
McCabe, Kiah (2017-09-22)It has been over 50 years since the first demonstration that levodopa was capable of reversing the motor dysfunction associated with Parkinson’s disease. In the intervening decades, although levodopa has remained the most ... -
Investigating the potential of targeting the CB2 receptor for anti-inflammatory disease modification in Parkinson’s disease
Kelly, Rachel (NUI Galway, 2021-10-22)Parkinson’s disease is a multifaceted neurodegenerative disorder that currently has no cure. Chronic neuroinflammation is thought to play a crucial role in the progression of the disease, with neuroinflammation and ... -
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
Alamilla Marroquín, Verónica Rebeca (NUI Galway, 2020-03-05)Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ... -
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
Moriarty, Niamh (NUI Galway, 2018-10-04)Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...