Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 69-88 of 2244
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Analysis of MiRNA Expression and Biomarker Potential in Common Diseases: Breast Cancer and Obesity
(2012-05-28)The two greatest health concerns worldwide at present are cancer and obesity; both of which continue to rise in incidence and are associated with high morbidity and mortality. Understanding the aetiology and mechanisms of ... -
Analysis of putative somatic mutations in 200,000 human exomes
(NUI Galway, 2023-09-19)Somatic mutations accumulate throughout life and contribute significantly to disease risk. While research into somatic mutation is well established in cancer, it is only in recent years that investigations into the ... -
Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Analysis of the behaviour of hybrid concrete lattice girder slabs during construction using laboratory and field testing
(NUI Galway, 2020-01-31)One of the emerging technologies in construction is the development of ‘smart structures’ which have sensors which will allow more efficient, resilient and sustainable structures to be designed and constructed. This research ... -
Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
An analysis of the health risks associated with international travel
(2015-01-28)This thesis, submitted for the award of a doctoral degree in Medicine, represents an attempt to collate all of my original research projects in travel medicine completed at NUI Galway. Chapter 1 presents four projects ... -
Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
(NUI Galway, 2018-09-28)Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ... -
Analysis of the role of Rho GTPases in epithelial cells
(2014-11-19)Rho GTPases are a family of small GTP binding proteins that function as molecular switches for the control of a variety of fundamental cellular processes, and therefore represent potentially vital proteins for skin ... -
Analytical and Computational Methods for Analyzing Feedback Structure in System Dynamics Models
(2012-07-10)The system dynamics approach is based on the observation that dynamic behaviour arises as a result of endogenous interactions, particularly the interplay of various feedback loops. There are many open questions relating ... -
Ancient Greek lexical semantics: Word meanings as a function of context
(NUI Galway, 2023-10-22)In 1989, Johannes Louw highlighted several problems in the study of Ancient Greek Lexical Semantics; 3 many remain unresolved. Louw’s rst diculty was that the etymology of a word is seldom a reliable indicator of ... -
Anglicisms in German radio media: A comparative study of the public service and private broadcasting sector
(NUI Galway, 2020-03-02)This thesis investigates the usage of anglicisms as mobile linguistic resources in both public service and private radio media in Germany. In previous research on anglicisms not much attention has been given to the medium ... -
Anisotropy resolved multi-dimensional emission spectroscopy (ARMES): a new tool for the quantitative and structural analysis of proteins
(NUI Galway, 2016-03-24)The quantitative and structural analysis of proteins is of great importance in numerous fields (from industrial to academic research). Requirements like ease of analysis, sample handling, robustness, analysis time, the ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) as a tool for biophysical analysis
(NUI Galway, 2021-10)The development of analytical tools for the biophysical analysis of biological samples is an area of tremendous application and potential. In this work the use and efficacy of an analytical methodology, known as anisotropy ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
(NUI Galway, 2018-11-14)Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) for the analysis of Immunoglobulin G (IgG) type proteins
(NUI Galway, 2020-10-02)Immunoglobulin G (IgG) is the main antibody used in the biopharmaceutical industry for therapeutic purposes. Monoclonal antibodies (mAb) are growing in the marked due to its high specificity and safety. Physical and ... -
The anomerisation of glycosidic linkages
(2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
(2015-04-29)There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ... -
Anti-Inflammatory Gene Therapy for the Promotion of Implanted Stem Cell Survival in Infarcted Myocardium
(2011-04-13)Cardiovascular disease is the leading cause of death in the developed world and is responsible for approximately 36% of Irish mortality. Myocardial infarction (MI), which is literally the death of cardiac tissue due to ... -
Anti-inflammatory hydrogel enrichment for cell-based brain repair in Parkinson's disease
(NUI Galway, 2020-01-28)Cell transplantation as a therapeutic approach for Parkinson’s disease has been extensively studied over the past decades. The transplantation of primary dopaminergic neurons in the degenerated striatum has shown that these ... -
Antimicrobial prescribing and resistance in Irish general practice
(2011-04-20)The emerging problem of antimicrobial resistance in bacterial pathogens is complex and the result of individual and population factors. Antimicrobial agents are unique therapeutics in that their impact goes beyond the ...