Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 501-520 of 2244
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Development of a nested 3D hydrodynamic model for tidal turbine impact assessment
(2016-05-12)Tidal current energy resources have the potential to provide a sizable proportion of our future energy requirements. However, significant questions still exist on the impacts of tidal turbines on the hydrodynamic environment. ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Development of a novel water quality index model using data science approaches
(NUI Galway, 2023-05-30)The thesis present the Irish Water Quality Index (IEWQI) model for assessing transitional and coastal water quality in an effort to improve the method and develop a tool that can be used by environmental regulators to abate ... -
The development of a novel, pre-deployment resilience building programme for Irish defence forces personnel
(NUI Galway, 2022-06-27)Background: Military personnel are, by the nature of their profession, at an increased risk of exposure to potentially traumatic events. Military personnel are also exposed to chronic stress caused by work related factors ... -
Development of a Probabilistic Multi-Zone Multi-Source Computational Model for Indoor Air Pollution Exposure Assessment
(2014-02-12)Airborne Particulate Matter (PM) is a major environmental concern because of its known impacts on human health, and since the developed world population spends approximately 89% of its time indoors, PM in the indoor ... -
Development of a psychometric measure of physical post traumatic growth in prostate cancer and evaluation of its role in predicting psychological adjustment
(2015-01-30)Post traumatic growth (PTG) can be defined as positive change following a traumatic event (Tedeschi & Calhoun, 1995). The current conceptualisation of PTG encompasses five main dimensions: perceived changes in self; ... -
Development of a standardised assessment methodology relating to flexibility analysis for demand response
(NUI Galway, 2020-09-28)Power and energy flexibility in buildings and sites is an integral part of the solution to address the electrical grid’s challenges posed by increasing renewable generation, decarbonisation of the electricity supply and ... -
The development of a survey instrument to evaluate women’s experiences of their maternity care in Ireland
(NUI Galway, 2020-06-08)Introduction The value of survey instruments in measuring the quality of maternity care from the perspective of service users is well recognised. Many countries, including, for example, the UK, USA and Australia use ... -
Development of a targeting mechanism for regeneration of the intervertebral disc
(2014-11-24)Degeneration of the intervertebral discs (IVD) is a leading cause of neck and low back pain. While its aetiology is poorly understood, it is known to begin in the central nucleus pulposus region, leading to degradation of ... -
Development of a tidal flow model for optimisation of tidal turbine arrays
(2018-02-19)Tidal current turbines have the potential to provide a proportion of global energy requirements. Installations to date have been singular test devices but commercial application will involve multiple devices deployed in ... -
Development of a Two-Dimensional Estuarine Hydrodynamic Model in Cylindrical Co-ordinates
(2014-02-03)Development of a novel two-dimensional estuarine hydrodynamic model in cylindrical co-ordinates is presented herein. The full non-linear Navier-Stokes equations are written in cylindrical co-ordinates with the advantage ... -
Development of advanced numerical models for concentrically braced steel frame members and components
(NUI Galway, 2018-09-18)The behaviours of braced steel frame members and components are investigated in this project using finite element models that were developed to address the multi-scale mechanics of braced steel frame structures. The ... -
The development of ambidexterity as a key dynamic capability for eco-innovation in SMEs: an action research study
(NUI Galway, 2018-10-17)Eco-innovation represents a discontinuous change, global in nature and comparable only to the industrial revolution. The scale of both environmental and economic challenges in the global economy highlights an unprecedented ... -
Development of an efficient dynamically nested model for tidal hydraulics and solute transport
(2010-06)Numerical modelling of coastal zones typically requires a high spatial resolution to accurately simulate land-sea interactions, particularly in areas of complex coastlines. As a result, the computational cost of coastal ... -
The development of an online intervention for post-treatment cancer survivors with cancer-related fatigue
(2017-02-02)Background The number of post-treatment cancer survivors in Ireland is set to increase in coming years, due to advances in screening and treatment. This group will require ongoing supportive care as many will experience ... -
Development of anisotropic polymeric substrates for tendon tissue engineering
(2015-09-11)Tendon injuries and degenerative conditions constitute an unmet clinical need with pharmacological strategies and tissue grafts failing to recapitulate native tendon function. Advancements in bioengineering have enabled ... -
Development of bioabsorbable polymeric textile scaffolds for tissue engineering applications
(NUI Galway, 2023-12-18)Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Tissue engineering aims to solve such problems by combining highly porous biomaterial scaffold with cells ... -
Development of computationally efficient nested hydrodynamic models
(2014-04-25)Hydrodynamic numerical modelling of coastal zones typically requires a high level of horizontal spatial resolution to improve the realism of its solution, particularly in areas of complex bathymetry. These high resolution ... -
Development of correlated and computational methods for predicting premixed turbulent flame speed
(NUI Galway, 2018-10-02)Turbulent flame speed is an important property within turbulent flames and an invaluable parameter for gas turbine combustor design. A major issue however is the difficulty in accurately predicting turbulent flame speed ... -
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...