Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 206-225 of 2213
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Calendars, feasting, cosmology and identities: later Neolithic-early Bronze Age Ireland in European context
(2016-07-25)The aim of the study is to investigate the connections between calendar systems, large-scale feasting activities, changing representations of cosmological ideas and the formation of group identities from the Middle/Late ... -
Calibrated whole building energy simulation: An evidence-based methodology
(2011-01)Climate change, driven by global energy consumption, is one of the major challenges to humanity today. The buildings sector consumes a significant portion of global energy resources and much of this is due to inefficient ... -
Calibration of detailed building energy simulation models to measured data using uncertainty analysis
(2014-05-30)Over the past few decades, advances in technology, most notably the industrial revolution of the late 18th-century, has brought about dramatic improvements in the socioeconomic circumstances of developed nations. This has ... -
Calixarene-mediated protein assembly
(2014-05-23)Solved the first crystal structure of a protein-calixarene complex (at 1.4 Angstrom resolution). The results provide exact structural information on the amino acid preference of the anionic p-sulfonatocalix[4]arene (sclx4) ... -
The cannabinoid type-2 (CB2) receptor as a target for anti-inflammatory disease modification in Parkinson's disease
(2016-08-04)Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ... -
Caointeoireacht na Gaeilge: Béalaireacht agus Literathacht
(2012-09-19)Tá deighilt láidir idir scoláirí Gaeilge maidir leis an mbéalaireacht agus an litearthacht sa chaoineadh. Ar láimh amháin, maítear gur seánra béil é an caoineadh a bhfuil fianaise de ar fáil i lámhscríbhinní, agus ar an ... -
Capability architecture for open data
(NUI Galway, 2018-07-31)Open data is increasingly becoming an essential asset for many organizations. Large numbers of new start-ups are emerging to benefit from the potential of this asset for a wide range of new products and services. However, ... -
Carbohydrates as precursors to macrocyclic and iminosugar frameworks
(2017-09-30)Natural products have been perceived as privileged structures in drug discovery based on their evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal chemists to identify some ... -
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)This thesis deals with efforts to generate new bioactive organic compounds. The main focus has been on the use of carbohydrate building blocks for synthesis of both macrocyclic compounds and glycoclusters for biological ... -
Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
(NUI Galway, 2018-11-27)The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ... -
Carbonization of polyimide using CO2 laser and femtosecond laser for sensor applications
(NUI Galway, 2023-10-05)Laser carbonization is the process of photothermal conversion of polymers rich in aromatic carbons such as Polyimide (PI) into graphene, via a process called Laser Induced Graphene (LIG) using a laser as the source of ... -
Cardiovascular disease and functional ability in older adults
(2015-06-03)Preservation of functional independence is important to older adults. The consequences of functional impairment (increased dependence on others for activities of daily living and requirement for nursing home care) place a ... -
Care and control: The experience of the Sisters of Mercy run Irish industrial school system, 1868-1936
(NUI Galway, 2022-09-20)This thesis is a historical investigation into the experience of the Catholic Sisters of Mercy run Irish industrial schools, from the introduction of the system in 1868 to the publication of the Cussen Report in 1936. It ... -
A Carnivalesque Mirage: the Orient in Isabelle Eberhardt's Writings
(2012-12-10)As a woman who traversed the North African Orient in male costume, who spoke Arabic as well as French, who professed Islam while transgressing many of its instructions, Isabelle Eberhardt seems to fit within Mikhail Bakhtin¿s ... -
Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold. Materials and Methods: To achieve this goal, a bovine explant model and two pilot ... -
Cataloguing and linking publicly available biomedical SPARQL endpoints for federation - addressing aPosteriori data integration
(2017-05-12)During recent years the increasing adoption of Open Data Initiatives and Lined Data principles have lead to the creation of a globally distributed space of Linked Data that covers various domains such as Government, ... -
CDC7 kinase promotes replication DNA double-strand breaks upon replication fork stalling and its inhibition causes an inflammatory response and senescence
(NUI Galway, 2022-12-08)CDC7 is an essential serine-threonine kinase that has an important role in the initiation of DNA replication. CDC7 phosphorylates several sites of the MCM helicase complex allowing recruitment of CDC45, among other factors, ... -
CDC7 kinase regulates DNA replication fork processing and its inhibition is modulated by PTBP1
(NUI Galway, 2022-09-21)CDC7 is an essential serine/threonine kinase that regulates the initiation of DNA replication by phosphorylating several sites of the MCM helicase complex. Several inhibitors of CDC7 are available that reduce cell proliferation ... -
Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ...