Browsing University of Galway Theses by Author "Samali, Afshin"
Now showing items 1-15 of 15
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A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
Leuzzi, Brian (NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
McCarthy, Nicole (NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
Pakos-Zebrucka, Karolina (2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
Saveljeva, Svetlana (2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ... -
Decoy Receptors block tumour cell eradication by TRAIL - Molecular engineering of TRAIL to evade decoy receptors
O' Leary, Lynda (2012-06-29)Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine expressed by immune cells which selectively eradicates a wide range of cancer cells while leaving normal healthy cells unharmed. TRAIL binds ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
Creedican, Stuart (NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
Nandy, Argha (NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ... -
Identification and validation of novel targets of regulated IRE1-dependent decay in triple negative breast cancer
Bolger, Alice (NUI Galway, 2023-08-16)Breast cancer is the most commonly diagnosed cancer in women. Triple-negative breast cancer (TNBC) refers to a subtype which lacks oestrogen receptors (ESR1), progesterone receptors (PR) and does not overexpress Human ... -
Investigating the role of IRE1α RNase activity in breast cancer
McGrath, Eoghan Patrick (NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
Cleary, Patricia (2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ... -
The molecular characterization of ER stress-induced autophagy and cell death
Deegan, Shane (2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
NGF-induced pro-survivla signalling: Molecular engineering of NGFto enhance pro-survival signalling
Carleton, Laura (2014-01-27)Nerve growth factor (NGF) is a potent pro-survival growth factor that has diverse roles in development and in the adult nervous system. It has two cognate receptors that stimulate distinct signalling pathways, tropomyosin-related ... -
The regulation of ER stress induced cell death by HSPB1 (hsp27)
Kennedy, Donna (2013-01-29)Endoplasmic reticulum (ER) stress is associated with several human pathologies including neurodegenerative disorders. ER stress results in accumulation of unfolded proteins which activates the unfolded protein response ... -
The role of IRE1α in the regulation of cytokine production
Talty, Aaron (NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ... -
The role of microRNAs during endoplasmic reticulum stress induced cell death
Cawley, Karen (2012-04-25)Endoplasmic Reticulum (ER) stress occurs in response to negative insult or stimuli to the cell. It induces a pathway called the unfolded protein response (UPR) which can alleviate stress and restore the cell to its ¿healthy ...