Browsing University of Galway Theses by Author "Ritter, Thomas"
Now showing items 1-9 of 9
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Allogeneic cell therapy for osteoarthritis
Lohan, Paul (2016-05-11)Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ... -
Enhancing the immunomodulatory capacity and therapeutic potential of mesenchymal stromal cell-derived small extracellular vesicles through cytokine licensing
Donohoe, Ellen (NUI Galway, 2023-09-12)The immunomodulatory capacity of mesenchymal stromal cells (MSCs) is well established, and is being explored as a cellular therapy for the treatment of various inflammatory-based conditions. In recent years, the role of ... -
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
Canning, Aoife (NUI Galway, 2024-04-17)The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ... -
Ex vivo generation of bone marrow derived regulatory dendritic cells for promotion of corneal allograft survival.
O'Flynn, Lisa (2013-09-27)Investigations into cell based therapies for application in organ transplantation has grown significantly. Here, I describe the ex vivo generation of donor bone marrow derived dendritic cells (BMDCs) and examine the ... -
Ex-vivo generation of regulatory T-cells expressing transcription factor foxp3 and their application in cornea transplantation
Maenz, Martin (2011-05-27)This project investigated the therapeutic potential of allo-antigen specific regulatory T-cells in the context of penetrating keratoplasty. Two methods of ex-vivo generation of T regulatory cells have been explored in ... -
Mechanistic insights into novel cellular therapy strategies for the treatment of corneal allograft rejection
Lynch, Kevin (NUI Galway, 2019-02-14)It has previously been demonstrated by our lab that tolerogenic dendritic cells (tDCs) prolong corneal allograft survival. This study revealed that tDCs had significantly higher levels of sialic acid on the cell surface ... -
Mesenchymal stem cells for therapeutic application in corneal transplantation
Treacy, Oliver (2014-02-12)Although corneal transplantation success rates are high within the first year, the prognosis is much less favourable 5 years post-transplantation with immune-mediated rejection the primary cause of allograft failure. For ... -
Novel gene therapeutic approaches to prolong corneal allograft survival
Wilk, Mieszko (2012-09-28)Cornea transplantation (penetrating keratoplasty) is the most frequent form of allograft transplantation in humans with a 90 % success rate in the first 2 years, however, the rate of survival decreases over time and drops ... -
Pro-inflammatory cytokine licensing as a strategy to enhance the efficacy of syngeneic mesenchymal stem cells for corneal transplantation
Murphy, Nick (NUI Galway, 2018-05-11)It has previously been demonstrated by our lab that allogeneic MSCs prolong corneal allograft survival however syngeneic MSCs fail to do so. The aim of this study was to investigate if pre-treating syngeneic MSCs with ...