Browsing University of Galway Theses by Subject "Pain"
Now showing items 1-6 of 6
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Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
(2016-09-21)The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ... -
Interferon alpha-induced changes in emotional and nociceptive processing: involvement of the endocannabinoid system
(2015-11-13)Interferon-α (IFN-α) is a pro-inflammatory cytokine used for the treatment of hepatitis B and C as well as various malignancies. However, therapy is often associated with neuropsychiatric side effects, including depression ... -
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
(2012-03-24)Abstract Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ... -
Regulation of fear, anxiety and cognition in the presence or absence of pain by peroxisome proliferator-activated receptors
(NUI Galway, 2019-06-07)Fear/anxiety and pain modulate one another reciprocally, but the neurobiological mechanisms that underlie this interaction are not completely understood. Fear-conditioned analgesia (FCA) is pain suppression upon exposure ... -
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ...