Browsing University of Galway Theses by Subject "Natural Science"
Now showing items 1-20 of 21
-
A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
(NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
Cell fate commitment during nervous system establishment: from stem cells to neurons
(NUI Galway, 2020-07-06)Members of the early-branching metazoan phylum of Cnidaria are well-recognized as a sister group to bilaterians making them an ideal candidate to study the evolution of the eumetazoan nervous system. I began to unravel the ... -
Copper complexes coupled to nucleosides, bile acids and histone deacetylase inhibitors.
(NUI Galway, 2019-12-10)The aim of this project is to synthesize and characterise novel inorganic complexes which consist of metal-based DNA cleavage entities coupled to biomolecules. It is hoped that the coupling of known DNA cleavage agents to ... -
Developing an integrated approach to seaweed resource assessment
(NUI Galway, 2020-09-01)Increasing interest in the sustainable management of Irish macroalgal resources requires the development of a cost-effective and efficient methodology for quantifying the distribution of key species. Remote sensing provides ... -
Developing climate smart agriculture: Insights from Indonesia, Vietnam, Malawi and Ireland
(NUI Galway, 2019-11-18)The present and future challenges to agricultural development and food security are immense. The agricultural sector is a significant driver of climate change, but at the same time, is highly vulnerable to its impacts. ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Environmental aqueous geochemistry of arsenic in groundwater: occurrence, speciation and biogeochemical processes
(NUI Galway, 2020-04-27)The presence of arsenic and other trace elements within groundwater has become a global concern due to the health risks from drinking water associated with elevated concentrations in the last three decades. Whilst ample ... -
Functional effects of inter-genome interactions on seed development in Arabidopsis thaliana
(NUI Galway, 2022-01-14)Plant seed size determination is of high economic interest for modern food production worldwide as many crops are mainly consumed in the form of seeds, such as rice, wheat or corn. Parental conflict and genomic imprinting ... -
Functional screening of human faecal microbiome metagenome library for glycoside hydrolase enzymes
(NUI Galway, 2020-04-24)Members of the human gut microbiota use glycoside hydrolase (GH) enzymes, such as sialidases, α-fucosidases and β-galactosidases to forage on host mucin glycans and dietary fibers. A human faecal metagenomic library was ... -
Genetic basis for dosage sensitivity of seed size heterosis in Arabidopsis thaliana
(NUI Galway, 2021-09-08)Heterosis refers to the ability of the F1 offspring to display superior characteristics compared with their parents and despite being genetically studied since the early 1900s, many aspects of this phenomenon remain unclear. ... -
Genomic and transcriptomic investigations into the feed efficiency phenotype of beef cattle
(NUI Galway, 2019-03-06)Improving the feed efficiency of cattle is a method to increase profits while simultaneously reducing the environmental impact of beef production. Residual feed intake (RFI) is a measure of feed efficiency, calculated as ... -
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ... -
Integrative evaluation of Tetanocera elata (Diptera: Sciomyzidae) for slug pest management in agriculture
(NUI Galway, 2019-09-25)Terrestrial gastropods are pervasive pests, especially of agriculture in temperate regions. While current management options exist, they primarily consist of baited pellets with active ingredients such as methiocarb or ... -
An investigation of the contribution of centrosomal genes to schizophrenia and cognitive function
(NUI Galway, 2020-03-11)The centrosome is the key microtubule organising centre of animal somatic cells. Centrosomes play a crucial role in brain development, influencing cell shape, polarity, motility, and division. The older of the two barrel-shaped ... -
Linking microbial community structure and function to process performance and reactor configuration during high-rate low-temperature anaerobic treatment of dairy wastewater
(NUI Galway, 2018-09-14)Anaerobic digestion is a sustainable and attractive option for the treatment of wastewaters. It allows the recovery of energy from waste - in the form of biogas - and is more cost-efficient than aerobic biological treatments. ... -
Mechanisms of bone marrow-mediated drug resistance in acute myeloid leukaemia
(NUI Galway, 2020-06-12)Acute myeloid leukaemia (AML) is a heterogenous clonal disorder characterised by the accumulation of immature, non-functional and highly proliferative blasts in the bone marrow and periphery. AML has a high relapse rate, ... -
Microbial ecology of E.coli removal mechanisms and drinking water production in slow sand filters exposed to emerging contaminants
(NUI Galway, 2019-04-19)Slow sand filters (SSFs) are a water treatment technology which can produce high quality water through a combination of physical and the activity of their microbial community. SSFs are easy to operate and have and low ... -
Nematode response to nitrogen and phosphorus in grasslands, assessed by microscopy and molecular methods
(2012-09-19)Although nematode community analysis is considered to be a useful environmental indicator, a major impediment to its wider adoption is the need for detailed morphological identification. Molecular techniques offer an ... -
A rational computer-aided drug discovery approach to target IRE1 and PERK: Insights into structural dynamics and selectivity
(NUI Galway, 2020-05-18)Cells constantly monitor the number of misfolded proteins they accumulate. The accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers an evolutionarily conserved signaling pathway called the unfolded ... -
The role of IRE1α in the regulation of cytokine production
(NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ...