Browsing University of Galway Theses by Author "Laffey, John"
Now showing items 1-5 of 5
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Characterisation and analysis of Memory T-cells in COVID-19 patient sample
Ho, Hai Wen (NUI Galway, 2023-08-08)Background: Immunological memory is the key to long-term protection against disease. It is the hallmark of adaptive immunity which facilitates an accelerated and enhanced immune response against a pathogen encountered ... -
Investigation of the role of nuclear factor kappa-B in mediating the effects of hypercapnic acidosis and mesenchymal stem cells in ventilation induced lung injury
Ansari, Bilal Mustafa (NUI Galway, 2016-11-08)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ... -
Role of gastro-oesophageal reflux in the development and severity of bronchiectasis
McDonnell, Melissa (NUI Galway, 2020-07-30)Background: Bronchiectasis is a chronic lung disease associated with significant morbidity and mortality, escalating public health costs and profound reductions in health-related quality of life (QoL). Comorbidity is a ... -
Therapies for acute respiratory distress syndrome: determination of the mechanisms of action of hypercapnia and the therapeutic efficacy of mesenchymal stromal cells
Horie, Shahd (2016-09-20)Rationale: Acute Respiratory Distress Syndrome (ARDS) causes severe respiratory failure and is associated with high mortality. Pharmacological therapies are non-existent and supportive ventilation treatments are limited. ... -
Understanding the Mechanisms of Action of Hypercapnic Acidosis and the Therapeutic Potential of Human Mesenchymal Stromal Cells in Diminishing Inflammation and Enhancing Repair in Acute Respiratory Distress Syndrome.
Masterson, Claire (2013-09-30)Acute respiratory distress syndrome (ARDS) is a term used to describe severe lung injury characterised by uncontrolled inflammatory response and resultant damage to endothelial and epithelial layers leading to eventual ...