Browsing University of Galway Theses by Author "Griffin, Matthew D."
Now showing items 1-6 of 6
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The glycosylation signature of human urinary extracellular vesicles
Krueger, Anja (2015-12-22)Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ... -
Immunomodulation of the T-helper 17 Cell Lineage by Mesenchymal Stem Cells
Duffy, Michelle M. (2012-11-20)T-helper 17 (Th17) cells play a pathogenic role in multiple sclerosis, inflammatory bowel disease, psoriasis, acute kidney injury, glomerulonephritis and transplant rejection. Mesenchymal stem cells (MSCs) are immunosuppressive ... -
Intra-Renal Inflammation in Obesity and Type 2 Diabetes Mellitus
McNicholas, Bairbre Aine (2013-09-30)Introduction: Unhealthy diet and sedentary lifestyle, lead to the constellation of obesity, hyperinsulinaemia and hyperlipidaemia that are risk factors for both chronic kidney disease and type 2 Diabetes mellitus. Renal ... -
Isolation and characterisation of immune modulatory extracellular vesicles from CD362-selected human umbilical cord mesenchymal stromal cells
Conroy, Callum Michael (NUI Galway, 2021-07-28)Mesenchymal stromal cells (MSCs) exert numerous therapeutic effects, including immunomodulatory and anti-inflammatory effects in vitro and in vivo, which are being explored as a treatment for many unmet medical needs. These ... -
Phenotypic and functional characteristics of blood monocytes in chronic kidney disease
Naicker, Serika D. (2017-02-15)Human blood monocytes, recently classified as classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14-CD16++) are reported to be dysregulated in chronic kidney disease (CKD) and may play a role in ... -
The role of glycosylation in regulatory T-cell biology
Faria Ferreira Cabral, Joana Maria (2016-12-14)Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ...