Browsing University of Galway Theses by Subject "Gene expression"
Now showing items 1-6 of 6
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Clinical Applications of Molecular Profiling in Colorectal Cancer
(2011-06)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Estimation and analysis of gene expression and alternative splicing: perspectives from development and disease
(2014-01-30)The development of high-throughput genomics technologies has contributed substantially to the understanding of gene expression regulation. With the growing appreciation of the importance of alternative splicing, quantitative ... -
Investigation of intron coevolution and the autoimmune potential of alternative splicing
(2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
Novel insights into the molecular roles of UBP5 in controlling chromatin dynamics and plant development
(NUI Galway, 2023-04-03)Polycomb group (PcG) proteins are conserved chromatin regulators essential for controlling key developmental programs in eukaryotes. PcG proteins assemble together to form multi-protein complexes known as Polycomb ... -
Regulation Of Myometrial Gene Expression By Oestrogen And Progesterone: The Use Of A Cell Culture Model To Mimic The In Vivo Conditions Of Pregnant Human Uterus
(2012-12-31)Pregnancy and labour are physiological events controlled by a complex interplay between maternal and foetal factors. These processes are diverse and specific to each species, hence simple extrapolation from model organisms ... -
Wnt signalling in the hydrozoan Hydractinia echinata
(2013-09-11)Canonical Wnt signalling controls many developmental processes in metazoans including primary axis formation in embryonic development and stem cell decision making. The evolutionary history of Wnt signalling and its ancestral ...