Browsing University of Galway Theses by Author "Flaus, Andrew"
Now showing items 1-6 of 6
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Characterisation of core histone sequences and nuclear mobility using a reproducible research approach
Susano Pinto, David Miguel (2017-09-19)Chromatin is a dynamic complex that controls access to genetic information by undergoing structural reconfigurations. Understanding this dynamic can provide insights into the biological implications of chromatin ... -
Contribution of non-histone proteins to chromatin structure and stability
Browne, Martin J. G. (2015-10-30)Histones are responsible for packaging the genomes of almost all eukaryotes into fundamental repeating nucleosome units. The packaging must facilitate compaction into the cell nucleus but also enable dynamic access to the ... -
Dynamics of GFP tagged chromatin factors RSF1, CENPS and CENPX at microirradiation induced DNA damage sites
Tidke, Pritishkumar (NUI Galway, 2022-02-22)Chromatin has a major influence on the DNA damage response (DDR). Several chromatin-related factors contribute to the DDR including the CENPS and CENPX histone fold proteins, also known as MHF1 and MHF2, and the chromatin ... -
Implications of histone H2AX abundance in breast cancer
Passos, Joana (NUI Galway, 2019-12-09)Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ... -
Properties of nucleosomes from divergent eukaryotes
Patwal, Indu (2014-10-31)It is widely assumed that eukaryotes package their genomes in equivalent chromatin structures. To test whether divergent eukaryotes form equivalent nucleosomes we selected eight organisms with completely sequenced genomes ... -
Site-directed mapping of nucleosome structure and dynamics in vitro
Doran, Jonathan (2013-03-04)The nucleosome core particle is the most basic unit of chromatin packaging. It is composed of an octamer of two each of the histone proteins H2A, H2B, H3 and H4 wrapped in ~147 bp of DNA. Nucleosome positioning and sliding ...