Browsing University of Galway Theses by Subject "Depression"
Now showing items 1-7 of 7
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Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ... -
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ... -
Interferon alpha-induced changes in emotional and nociceptive processing: involvement of the endocannabinoid system
(2015-11-13)Interferon-α (IFN-α) is a pro-inflammatory cytokine used for the treatment of hepatitis B and C as well as various malignancies. However, therapy is often associated with neuropsychiatric side effects, including depression ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
Modelling early life exposure to antidepressants in rats: Developmental, behavioural and neurochemical aspects
(2013-02-11)Depression during pregnancy and the postpartum period has been associated with deleterious consequences such as preterm birth, low birth weight and less optimal scores on neonatal reflexes and behaviour. Pharmacological ... -
Stigma towards Peers with Mental Health Disorders in Childhood & Adolescence: An Investigation into Explicit & Implicit Stigma & Social Reasoning about Exclusion
(2013-09-30)Children and adolescents with mental health disorders are widely reported to have problems with peer relationships; however, few studies have explored the way in which their peers regard these young people. The literature ...