Browsing University of Galway Theses by Subject "DNA damage"
Now showing items 1-13 of 13
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Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
Biochemical and functional characterization of human MSL2
(2013-04-10)DNA in Eukaryotic cells is complexed with histone proteins to form chromatin. This mediates DNA packaging into the nucleus but also facilitates the regulation of all DNA-templated processes, including transcription, ... -
Centrobin functions in centriole duplication, primary ciliogenesis and genome maintenance
(2018-03-06)The centrosome is composed of numerous proteins that make up its core structure. Other proteins also transiently localise and interact with centrosomal proteins for functional modulation. Centrobin, one of the core centrosomal ... -
Centrosome cohesion: functions of C-NAP1
(2016-01-07)Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next. Detection of lesions ... -
Characterisation of novel ATM-interacting factors involved in double-strand break repair
(2012-10-22)Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ... -
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)The integrity of our genome is very important therefore, our cells have developed efficient DNA repair mechanisms to control this integrity and avoid mutations. Although the DNA double strand break response pathway is ... -
Impacts of DNA damage on the pericentriolar material and centriole duplication
(2015-12-03)The centrosome consists of two barrel-shaped centrioles embedded in a proteinaceous pericentriolar material (PCM), a highly organised scaffold that serves as a platform for proteins that regulate spindle assembly, protein ... -
KIF18B, a nuclear kinesin, is involved in DNA damage response
(NUI Galway, 2021-03-08)DNA damage from both exogenous and endogenous sources occurs continuously in all cells. A multitude of DNA repair mechanisms have evolved to maintain genome stability. The 53BP1 tumour suppressor has been identified as a ... -
The kinesin KIF18B interacts with 53BP1 and is required for efficient double strand break repair
(2015-11-19)Genetic changes can lead to detrimental genomic instability, mutagenesis, oncogenesis and premature aging. The DNA damage response (DDR) is responsible for safeguarding the genome from such harmful alterations. 53BP1 ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
Programmed DNA damage in myogenesis
(2017-02-23)Skeletal muscle is a major tissue type in humans, comprising approximately 40% of total body mass in adults. Skeletal muscle is ultimately composed of elongated multinucleate cells known as myofibers. These myofibers are ... -
A role for USP9X in homologous recombination repair of DNA double strand breaks
(NUI Galway, 2020-02-11)In order to prevent the deleterious effects of a variety of genotoxic agents, cells have developed complex surveillance mechanisms and multiple DNA repair pathways that allow them to maintain genome integrity. The ... -
Role of Rad9 cell cycle phosphorylation in the regulation of Chk1 activation
(2012-01-07)DNA damage checkpoints are triggered in response to DNA insults. Once activated, these pathways prevent replication and segregation of the damaged DNA. In addition to cell cycle delays they regulate repair, transcription ...