Browsing University of Galway Theses by Subject "53BP1"
Now showing items 1-4 of 4
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KIF18B, a nuclear kinesin, is involved in DNA damage response
(NUI Galway, 2021-03-08)DNA damage from both exogenous and endogenous sources occurs continuously in all cells. A multitude of DNA repair mechanisms have evolved to maintain genome stability. The 53BP1 tumour suppressor has been identified as a ... -
The kinesin KIF18B interacts with 53BP1 and is required for efficient double strand break repair
(2015-11-19)Genetic changes can lead to detrimental genomic instability, mutagenesis, oncogenesis and premature aging. The DNA damage response (DDR) is responsible for safeguarding the genome from such harmful alterations. 53BP1 ... -
Regulation and function of the tumour suppressor 53BP1 at sites of DNA damage
(2013-10-16)Cancer is the major cause of death for people in middle age. It results from cell transformation into malignant cells and propagates with normal controls. This process is induced by mutations occurring in DNA through the ... -
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
(2017-07-05)The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ...