Browsing University of Galway Theses by Subject "Cellular and Molecular Biology"
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A rational computer-aided drug discovery approach to target IRE1 and PERK: Insights into structural dynamics and selectivity
(NUI Galway, 2020-05-18)Cells constantly monitor the number of misfolded proteins they accumulate. The accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers an evolutionarily conserved signaling pathway called the unfolded ...