Browsing University of Galway Theses by Author "Dwyer, Róisín M."

Now showing items 1-10 of 10

    • Analysis of cytokine expression in breast cancer 

      Hartmann, Marion Charlotte (2014-10-29)
      Introduction: It has long been recognized that cancer develops in sites of chronic inflammation. Tumours seem to seize molecular pathways seen in wound healing and the inflammatory response and as a consequence appear as ...

    • Current and potential diagnostic modalities in the detection and management of breast cancer 

      Moloney, Brian Michael (NUI Galway, 2021-07-06)
      Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ...

    • Development of 3D breast cancer model to study extracellular vesicle crosstalk 

      Chabria, Yashna (NUI Galway, 2024-01-31)
      3D model systems are crucial in establishing novel therapeutics and understanding cell interactions in the tumor microenvironment. Extracellular vesicles (EVs) are promising carriers of therapeutic cargo for tumor-targeted ...

    • Exosomal microRNAs in colorectal cancer 

      Clancy, Cillian (2016)
      Cancer cells have been shown to release a variety of extracellular membrane vesicles including microvesicles known as exosomes. Exosomes have recently been found to contain microRNAs (miRNAs) however the full range within ...

    • Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer 

      Joyce, Doireann (2016-06-15)
      Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ...

    • Extracellular vesicle encapsulated microRNAs and breast cancer 

      O'Neill, Clodagh (NUI Galway, 2023-02-24)
      Breast cancer is the most prevalent cancer among women worldwide. There is a clear need for earlier detection methods and more personalised treatments. Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ...

    • microRNA-mediated intercellular communication in the primary breast tumour microenvironment 

      Glynn, Claire (2014-08-30)
      microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ...

    • MicroRNAs as biomarkers and therapeutics in breast cancer 

      O'Brien, Killian (2017-05-25)
      Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ...

    • MicroRNAs for the treatment of breast cancer 

      McCarthy, Elan (NUI Galway, 2024-01-12)
      MicroRNA-379 (miR-379) has been reported as a potent tumour suppressor miRNA with data supporting a potential therapeutic function in breast cancer. Despite this, the exact mechanism of action of miR-379 is still ...

    • Molecular mechanisms and tumour heterogeneity in breast cancer 

      Khan, Sonja (2014-05-07)
      MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ...