Browsing University of Galway Theses by Title
Now showing items 504-523 of 2273
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Development of a gene-eluting stent for the treatment of in-stent restenosis
(2016-05-12)In-stent restenosis (ISR) results from stent-induced arterial injury, characterized by a complex cascade of cellular and biochemical events. The removal of endothelium during an angioplasty procedure causes the underlying ... -
Development of a global energy management system for the non-energy intensive multi-site manufacturing organisations
(NUI Galway, 2018-09-30)Climate change and energy resource sustainability are both major challenges facing humanity today. Due to their scale, multi-site (and/or multi-national) manufacturing organisations (MMO), are large consumers of energy, ... -
Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell applications
(NUI Galway, 2021-08-04)Chemical compounds synthetized by living organisms have historically contributed to improved human health. Ancient populations made use of local natural products through herbal medicine, which today are to be found as ... -
Development of a high time resolution optical polarimeter for astronomy
(NUI Galway, 2018-12-17)This work started in September, 2014 and initially started as an investigation of the characterisation issues associated with using Electron Multiplying Charge- Coupled Devices (EMCCDs) in a two beam polarimeter. It was ... -
Development of a high-resolution gamma-ray imaging system with synthetic collimation.
(2013-11-01)This work outlines the development of a multi-pinhole single-photon emission computed tomography (SPECT) system designed to produce a synthetic-collimator image of a small field of view. The synthetic-collimator image was ... -
The development of a high-resolution nested bridge hydraulic model
(NUI Galway, 2023-11-23)Traditionally, hydraulic modelling of bridges has been undertaken using one dimensional models like HEC-RAS. One-dimensional models simplify river channels using several cross sections along a river curve and strongly ... -
Development of a mesenchymal stromal cell / collagen scaffold product for treatment of diabetic wounds
(NUI Galway, 2022-08-23)Foot ulceration is a major complication of diabetes mellitus, which results in significant human suffering and a major burden on healthcare systems. Mesenchymal stromal cells (MSCs) emerged as a promising therapeutic ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
(2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Development of a mixed glial in vitro robust platform for therapeutic applications in spinal cord injury
(NUI Galway, 2021-06-30)Spinal cord injury (SCI) is a catastrophic event, and current strategies for SCI pose several limitations. One of the critical hallmarks of SCI is inflammation, which is due to the activation of microglia and astrocytes. ... -
Development of a nested 3D hydrodynamic model for tidal turbine impact assessment
(2016-05-12)Tidal current energy resources have the potential to provide a sizable proportion of our future energy requirements. However, significant questions still exist on the impacts of tidal turbines on the hydrodynamic environment. ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Development of a novel water quality index model using data science approaches
(NUI Galway, 2023-05-30)The thesis present the Irish Water Quality Index (IEWQI) model for assessing transitional and coastal water quality in an effort to improve the method and develop a tool that can be used by environmental regulators to abate ... -
The development of a novel, pre-deployment resilience building programme for Irish defence forces personnel
(NUI Galway, 2022-06-27)Background: Military personnel are, by the nature of their profession, at an increased risk of exposure to potentially traumatic events. Military personnel are also exposed to chronic stress caused by work related factors ... -
Development of a Probabilistic Multi-Zone Multi-Source Computational Model for Indoor Air Pollution Exposure Assessment
(2014-02-12)Airborne Particulate Matter (PM) is a major environmental concern because of its known impacts on human health, and since the developed world population spends approximately 89% of its time indoors, PM in the indoor ... -
Development of a psychometric measure of physical post traumatic growth in prostate cancer and evaluation of its role in predicting psychological adjustment
(2015-01-30)Post traumatic growth (PTG) can be defined as positive change following a traumatic event (Tedeschi & Calhoun, 1995). The current conceptualisation of PTG encompasses five main dimensions: perceived changes in self; ... -
Development of a standardised assessment methodology relating to flexibility analysis for demand response
(NUI Galway, 2020-09-28)Power and energy flexibility in buildings and sites is an integral part of the solution to address the electrical grid’s challenges posed by increasing renewable generation, decarbonisation of the electricity supply and ... -
The development of a survey instrument to evaluate women’s experiences of their maternity care in Ireland
(NUI Galway, 2020-06-08)Introduction The value of survey instruments in measuring the quality of maternity care from the perspective of service users is well recognised. Many countries, including, for example, the UK, USA and Australia use ... -
Development of a targeting mechanism for regeneration of the intervertebral disc
(2014-11-24)Degeneration of the intervertebral discs (IVD) is a leading cause of neck and low back pain. While its aetiology is poorly understood, it is known to begin in the central nucleus pulposus region, leading to degradation of ... -
Development of a tidal flow model for optimisation of tidal turbine arrays
(2018-02-19)Tidal current turbines have the potential to provide a proportion of global energy requirements. Installations to date have been singular test devices but commercial application will involve multiple devices deployed in ... -
Development of a Two-Dimensional Estuarine Hydrodynamic Model in Cylindrical Co-ordinates
(2014-02-03)Development of a novel two-dimensional estuarine hydrodynamic model in cylindrical co-ordinates is presented herein. The full non-linear Navier-Stokes equations are written in cylindrical co-ordinates with the advantage ...