Browsing University of Galway Theses by Title
Now showing items 225-244 of 2275
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Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
(NUI Galway, 2018-11-27)The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ... -
Carbonization of polyimide using CO2 laser and femtosecond laser for sensor applications
(NUI Galway, 2023-10-05)Laser carbonization is the process of photothermal conversion of polymers rich in aromatic carbons such as Polyimide (PI) into graphene, via a process called Laser Induced Graphene (LIG) using a laser as the source of ... -
Cardiovascular disease and functional ability in older adults
(2015-06-03)Preservation of functional independence is important to older adults. The consequences of functional impairment (increased dependence on others for activities of daily living and requirement for nursing home care) place a ... -
Care and control: The experience of the Sisters of Mercy run Irish industrial school system, 1868-1936
(NUI Galway, 2022-09-20)This thesis is a historical investigation into the experience of the Catholic Sisters of Mercy run Irish industrial schools, from the introduction of the system in 1868 to the publication of the Cussen Report in 1936. It ... -
A Carnivalesque Mirage: the Orient in Isabelle Eberhardt's Writings
(2012-12-10)As a woman who traversed the North African Orient in male costume, who spoke Arabic as well as French, who professed Islam while transgressing many of its instructions, Isabelle Eberhardt seems to fit within Mikhail Bakhtin¿s ... -
Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold. Materials and Methods: To achieve this goal, a bovine explant model and two pilot ... -
Cataloguing and linking publicly available biomedical SPARQL endpoints for federation - addressing aPosteriori data integration
(2017-05-12)During recent years the increasing adoption of Open Data Initiatives and Lined Data principles have lead to the creation of a globally distributed space of Linked Data that covers various domains such as Government, ... -
CDC7 kinase promotes replication DNA double-strand breaks upon replication fork stalling and its inhibition causes an inflammatory response and senescence
(NUI Galway, 2022-12-08)CDC7 is an essential serine-threonine kinase that has an important role in the initiation of DNA replication. CDC7 phosphorylates several sites of the MCM helicase complex allowing recruitment of CDC45, among other factors, ... -
CDC7 kinase regulates DNA replication fork processing and its inhibition is modulated by PTBP1
(NUI Galway, 2022-09-21)CDC7 is an essential serine/threonine kinase that regulates the initiation of DNA replication by phosphorylating several sites of the MCM helicase complex. Several inhibitors of CDC7 are available that reduce cell proliferation ... -
Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Cell fate commitment during nervous system establishment: from stem cells to neurons
(NUI Galway, 2020-07-06)Members of the early-branching metazoan phylum of Cnidaria are well-recognized as a sister group to bilaterians making them an ideal candidate to study the evolution of the eumetazoan nervous system. I began to unravel the ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Cell wall immunocytochemistry and histology of hemiparasitism in Rhinanthus minor L. and Odontites vernus (Bellardi) Dumort: interactions at haustorial interfaces and implications for grassland biodiversity
(2013-11-21)Parasitic plants develop specialised grafting organs called haustoria to attach to and infiltrate host plant organs to access nutrients. The outcome of the parasitic process is largely determined where cell walls of the ... -
A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
(2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
(2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ... -
The centrality of the Galway hooker to dwelling in the island and coastal communities of south west Conamara
(NUI Galway, 2019-11-30)Abstract This research explores the relational nature of the Galway hooker, a traditional carvel-built wooden sail-boat described by Scott (2004) as “The Workhorse of Galway Bay” (Scott, 2004, p.22). It focuses on the ... -
Centriolar and ciliary responses to DNA damage
(2012-09-26)Centrosome duplication is tightly controlled and takes place only once every cell cycle. In recent years more light has been shed on the mechanism of centrosome duplication, with key players being identified and characterised. ...