Browsing University of Galway Theses by Title
Now showing items 182-201 of 2276
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Biological and chemical analysis of azaspiracids and amphidinols originating from dinoflagellate strains associated to Irish waters
(NUI Galway, 2024-04-15)Microalgae have the potential to produce biologically active metabolites which can be toxic, affect our fisheries and endanger food safety. Due to their active nature these toxins can also have therapeutic benefits when ... -
A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
(NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
Biological characterization of a human mesenchymal stromal cell product
(2016-07-21)The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ... -
The biology of the slug-killing Tetanocera elata (Diptera: Sciomyzidae) and its potential as a biological control agent for pestiferous slugs
(15-02-05)Laboratory experiments were carried out to determine the effects of controlled temperatures (14oC, 17oC, 20oC, 23oC, and 26oC) and ambient outdoor and laboratory temperatures on the development and predation capacity of ... -
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
(2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
(NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
A biomaterials approach to peripheral nerve repair
(2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
Biomimetic nano-biomaterials for bone repair and regeneration
(2017-02-24)Currently, over 1.7 billion people suffer from a musculoskeletal disorder; over 200 million operations take place annually; and in excess of 1 million new clinical cases are reported per year. Further, the annual healthcare ... -
Biophysical and biochemical microenvironmental cues for tenogenic phenotype maintenance, differentiation and trans-differentiation in vitro
(NUI Galway, 2019-07-19)Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years. ... -
Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Bioprocess monitoring using Polarised Multidimensional Fluorescence (pMDF) spectroscopy
(NUI Galway, 2022-06-15)Bioprocess monitoring is essential for biopharmaceutical manufacturing as it helps to ensure the required quality of the therapeutic proteins and maximise the productivity of the bioprocess as per Quality-by-Design (QbD) ... -
Biosafety assessment during anaerobic co-digestion of food waste and pig manure
(NUI Galway, 2022-10-11)Antimicrobial resistance (AMR) spreading has been a public concern as it increases the mortality of infection, and some biowastes (such as pig manure, food waste and municipal waste sludges) have been reported as hotspots ... -
Biosupramolecular protein tectonics
(NUI Galway, 2021-03-31)Taking a structural biology approach, this thesis describes in-depth investigations into protein bioconjugation (PEGylation), surface recognition (synthetic receptors), and ligand-mediated assembly (crystalline frameworks). ... -
Blood biomarker monitoring in professional soccer: Longitudinal analysis of inflammation in English Premier League players
(NUI Galway, 2021-09-06)The high intensity demands of elite soccer predispose players to recurrent episodes of acute inflammation, and during periods of frequent match play recovery time may not be adequate for the resolution of the inflammatory ... -
Body and Soul: Turning Turk in Early Modern Barbary captivity narratives
(2016-12-20)This thesis focuses on early modern Barbary captivity narratives which describe Christian encounters with the Islamic world, and gives particular attention to questions of sexuality and gender. From the short fledgling ... -
Bone marrow stromal cell transplantation ameliorates cytopenias caused by depletion of FAP-α expressing cells
(NUI Galway, 2018-05-03)Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ... -
Boolean games played in a triangle using bi-partite and tri-partite entanglement
(NUI Galway, 2024-04-17)This dissertation analyses the Nash equilibrium points in a triangle network when the three nodes/players are playing pairwise boolean games using bi-partite and tri partite entanglement. The players are given one bit as ... -
Booleying in Achill, Achillbeg and Corraun: survey, excavation and analysis of booley settlements in the Civil Parish of Achill
(2014-04-24)Transhumance, called booleying in Ireland, is a practice found in many parts of Europe that involves the movement of livestock and their keepers from lowland, permanent settlements to summer pasture, usually in the uplands, ... -
Borrowers and lenders in the residential mortgage context: legacy of the financial crisis on regulatory frameworks in Ireland and Spain
(2016-09-27)The Global Financial Crisis is clearly identifiable as a catalyst for reform of financial regulation and supervision in the period from 2008 onwards. It was also the starting point for the emergence of an indebtedness ...