Browsing University of Galway Theses by Author "SFI"
Now showing items 21-34 of 34
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Machine learning and high-performance computing: Infrastructure and algorithms for the genome-scale study of genetic and epigenetic regulatory mechanisms with applications in neuroscience
Ó Broin, Pilib (2014-06-30)The advent of next-generation sequencing (NGS) has fundamentally changed modern genomics re-search. These sequencers generate terabytes of data and necessitate the use, not only of high-performance compute (HPC) clusters ... -
Mapping protein architecture in centromeres of Equus asinus
Masterson, Teri Anne (2016-11-28)The centromere is a genetic locus present once per chromosome that specifies the site of kinetochore formation and is vital for chromosomal segregation. With the exception of Saccharomyces cerevisiae, whose ‘point’ ... -
A Native and Adaptive Approach for Linked Stream Data Processing
Le Phuoc, Danh (2013-04-08)Sensors, mobile devices and social platforms generate an immense amount of stream data in various formats and schemata. For these areas, the idea of Linked Stream Data is to extend RDF data model to cope with the heterogeneity ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
van Sluis, Marjolein (2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
McCarter, Joseph Gerald William (2017-02-15)Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ... -
Numerical Modelling and Measurement of Spatial Coherence in a Lithographic System
Smith, Arlene (2011-09-30)For the last five decades, optical lithography has been used universally for the manufacture of integrated circuits. The drive towards smaller circuit feature size, and the resulting increase in resolution of lithography ... -
An Ontological Framework for Interoperability of Health Level Seven (HL7) Applications: The PPEPR Methodology and System
Sahay, Ratnesh (2012-09-25)Healthcare applications are complex in the way data and schemas are organised in their internal systems. Healthcare standards have been proposed to reduce heterogeneities between healthcare applications. Widely deployed ... -
Organisation and function of the Nucleolar Organiser Regions in human chromosomes.
Floutsakou, Ioanna (2013-12-20)The short-arms of the five acrocentric human chromosomes contain sequences that direct the assembly and function of the nucleolus, one of the key functional domains of the nucleus and ribosomal biogenesis, yet they are ... -
A Probabilistic Framework Based on Mathematical Models with Application to Medical Data Streams
Enright, Catherine (2012-08-01)This thesis presents a new probability-based framework which exploits existing domain knowledge in the form of mathematical models and uses real-time data streams to individualise model parameters. We apply this new ... -
Proteins that modulate trinucleotide repeat expansions in human cells
Frizzell, Aisling (2012-09-18)Expansions of trinucleotide repeats (TNRs) are the genetic cause of several inherited neurological diseases, such as Huntington's disease, myotonic dystrophy and fragile X syndrome. TNR diseases and their causal expansion ... -
Regulation and function of the tumour suppressor 53BP1 at sites of DNA damage
Moureau, Sylvie (2013-10-16)Cancer is the major cause of death for people in middle age. It results from cell transformation into malignant cells and propagates with normal controls. This process is induced by mutations occurring in DNA through the ... -
The RNA-associated splicing-factor p54nrb regulates survival of human cells following UV irradiation
Corduff, Aoife (2013-04)UV radiation causes several forms of DNA damage; the most prominent of these are cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-photoproducts (6-4 PPs). Nucleotide excision repair (NER) is a repair process that ... -
Time-Resolved Fluorescence Spectroscopy of Crude Petroleum Oils
Owens, Peter (2009-03)Characterisation of crude oil properties in real-time by spectroscopic methods has been a major challenge to the oil industry. While current methods can show the presence of oil, a quantitative determination of oil ... -
Voltammetric Characterization of Macroalgae-Exuded Organic Ligands in Response to Metal Exposure
Murray, Hollydawn (2013-09-30)Trace metal availability, and hence toxicity, is largely dependent on metal speciation. It is well established that in seawater complexation by organic ligands dominates the speciation of most metals including Cd, Cu, Pb, ...