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Liposomal gene delivery mediated by tissue-engineered scaffolds

ARAN - Access to Research at NUI Galway

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dc.contributor.author Kulkarni, Mangesh en
dc.contributor.author Griser, Udo en
dc.contributor.author O'Brien, Timothy en
dc.contributor.author Pandit, Abhay en
dc.date.accessioned 2010-10-14T09:14:33Z en
dc.date.available 2010-10-14T09:14:33Z en
dc.date.issued 2010-01-01 en
dc.identifier.citation Kulkarni, M., Greiser, U., O'Brien, T., & Pandit, A. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends in Biotechnology, 28(1), 28-36. en
dc.identifier.issn 0167-7799 en
dc.identifier.uri http://hdl.handle.net/10379/1335 en
dc.description.abstract In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome¿scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions. en
dc.format application/pdf en
dc.publisher Elsevier en
dc.subject Non-viral gene delivery en
dc.subject Network of Excellence for Functional Biomaterials en
dc.title Liposomal gene delivery mediated by tissue-engineered scaffolds en
dc.type Article en
dc.local.publishedsource http://www.sciencedirect.com/science/article/B6TCW-4XM99F4-1/2/10e81833ae08e38bb0cb0ca9a0667bb8 en
dc.description.peer-reviewed peer-reviewed en
dc.contributor.funder Science Foundation Ireland en

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