Browsing School of Chemistry by Author "Zhou, Jian"
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Decorated macrocycles via ring-closing double-reductive amination. Identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor
Zhou, Jian; Reidy, Mairead; O'Reilly, Ciaran; Jarikote, Dilip V.; Negi, Arvind; Samali, Afshin; Szegezdi, Eva; Murphy, Paul V. (American Chemical Society, 2015-03-16)A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to ... -
Ligand design for somatostatin receptor isoforms 4 and 5
Negi, Arvind; Zhou, Jian; Sweeney, Sinclair; Murphy, Paul V. (Elsevier, 2018-11-17)The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ... -
N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
Zhou, Jian; Negi, Arvind; Mirallai, Styliana I.; Warta, Rolf; Herold-Mende, Christel; Carty, Michael P.; Ye, Xin-Shan; Murphy, Paul V. (Elsevier, 2018-12-04)1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the ¿-fucosidases of T. maritima (bacterial origin) ... -
Regiospecific anomerisation of acylated glycosyl azides and benzoylated disaccharides by using TiCl4.
Farrell, Mark; Zhou, Jian; Murphy, Paul V. (Wiley, 2013-10-25)Chelation induced anomerisation is promoted when Lewis acids, such as TiCl4 or SnCl4 , coordinate to the pyranose ring oxygen atom and another site, giving rise to endocyclic cleavage and isomerisation to the more stable ...