Browsing School of Chemistry by Author "Rode, Wojciech"
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Advanced spectroscopy and APBS modeling for determination of the role of His190 and Trp103 in mouse thymidylate synthase interaction with selected dUMP analogues
Prokopowicz, Małgorzata; Jarmuła, Adam; Casamayou-Boucau, Yannick; Gordon, Fiona; Ryder, Alan; Sobich, Justyna; Maj, Piotr; Cieśla, Joanna; Zieliński, Zbigniew; Fita, Piotr; Rode, Wojciech (MDPI, 2021-03-06)A homo-dimeric enzyme, thymidylate synthase (TS), has been a long-standing molecular target in chemotherapy. To further elucidate properties and interactions with ligands of wild-type mouse thymidylate synthase (mTS) and ...