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Ghrelin in the human myometrium

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dc.contributor.author O'Brien, Margaret en
dc.contributor.author Earley, Padraig en
dc.contributor.author Morrison, John J. en
dc.contributor.author Smith, Terry J. en
dc.date.accessioned 2010-05-31T11:17:39Z en
dc.date.available 2010-05-31T11:17:39Z en
dc.date.issued 2010-03-29 en
dc.identifier.citation O'Brien, M., Earley, P., Morrison, J., & Smith, T. (2010). Ghrelin in the human myometrium. Reproductive Biology and Endocrinology, 8(1), 55. en
dc.identifier.uri http://hdl.handle.net/10379/1133 en
dc.description.abstract Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human contractility in vitro. The aim of this study therefore, was to investigate the expression of ghrelin, its receptor, the growth hormone secretagogue receptor type 1 (GHS-R1), ghrelin O-acyltransferase (GOAT) which catalyses ghrelin octanoylation, prohormone convertase 1/3 (PC1/3) responsible for pro-ghrelin processing, in human myometrium, during pregnancy prior to labour, during labour and in the non-pregnant state. Modulation of ghrelin and ghrelin receptor expression in cultured myometrial cells was also investigated. en
dc.description.sponsorship Health Research Board of Ireland and the Higher Education Authority of Ireland (Program for Research in Third Level Institutions). en
dc.format application/pdf en
dc.language.iso en en
dc.publisher BioMed Central Ltd en
dc.subject Ghrelin en
dc.subject Growth hormone release en
dc.subject NCBES en
dc.title Ghrelin in the human myometrium en
dc.type Article en
dc.identifier.doi doi:10.1186/1477-7827-8-55 en
dc.local.publishedsource http://www.rbej.com/content/8/1/55 en
dc.description.peer-reviewed peer-reviewed en

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