ARAN - Access to Research at NUI Galway

Genetically Modified Mesenchymal Stem

ARAN - Access to Research at NUI Galway

Show simple item record Griffin, Matthew en Greiser, Udo en Barry, Frank en O'Brien, Timothy en Ritter, Thomas en 2010-05-24T14:05:41Z en 2010-05-24T14:05:41Z en 2010-03 en
dc.identifier.citation Griffin, M., Greiser, U., Barry, F., O'Brien, T., & Ritter, T. (2010). Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease. Discovery Medicine, 9(46), 219-223. en
dc.identifier.uri en
dc.description.abstract Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the capacity to extensively proliferate in vitro. Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses. Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases. However, the current understanding from results of clinical trials is that MSC-therapy is safe but its therapeutic efficiency needs to be improved. In this article we will focus on options for genetic manipulation of MSCs and on current progress in adapting genetically-modified MSCs for clinical use in acute cardiovascular disease. en
dc.description.sponsorship Health Research Board en
dc.format Application/pdf en
dc.language.iso en en
dc.subject Medicine en
dc.subject Regenerative medicine en
dc.subject Immunology en
dc.subject NCBES en
dc.title Genetically Modified Mesenchymal Stem en
dc.type Article en
dc.identifier.doi en
dc.description.peer-reviewed peer-reviewed en

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