Browsing by Author "Wang, Guan-Nan"
Now showing items 1-5 of 5
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A high through-put screen for small molecules modulating mcm2 phosphorylation identifies ryuvidine as an inducer of the dna damage response
FitzGerald, Jennifer; Murillo, Laura S.; O'Brien, Gemma; O'Connell, Enda; O'Connor, Aisling; Wu, Kevin; Wang, Guan-Nan; Rainey, Michael D.; Natoni, Alessandro; Healy, Sandra; O'Dwyer, Michael; Santocanale, Corrado (Public Library of Science (PLoS), 2014-06-05)DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has ... -
Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity.
Wang, Guan-Nan; Murphy, Paul V. (Royal Society of Chemistry, 2012-06-29)The emerging functional versatility of cellular glycans makes research on the design of synthetic inhibitors a timely topic. In detail, the combination of ligand (or headgroup or contact site) structure with spatial ... -
Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
Rainey, Michael; Harhen, Brendan; Wang, Guan-Nan; Murphy, Paul; Santocanale, Corrado (Informa UK Limited, 2013-05-15)Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ... -
Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)
Andre, Sabine; Wang, Guan-Nan; Gabius, Hans-Joachim; Murphy, Paul V. (Elsevier, 2014-05-07)Complementarity in lectin-glycan interactions in situ is assumed to involve spatial features in both the lectin and the glycan, giving a functional meaning to structural aspects of the lectin beyond its carbohydrate-binding ... -
Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach
Wu, Kevin Z. L.; Wang, Guan-Nan; Fitzgerald, Jennifer; Quachthithu, Huong; Rainey, Michael D.; Cattaneo, Angela; Bachi, Angela; Santocanale, Corrado (Oxford University Press (OUP), 2016-07-12)In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ...