Browsing by Author "Rea, Stephen"
Now showing items 1-7 of 7
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Biochemical and functional characterization of human MSL2
Moravcova, Simona (2013-04-10)DNA in Eukaryotic cells is complexed with histone proteins to form chromatin. This mediates DNA packaging into the nucleus but also facilitates the regulation of all DNA-templated processes, including transcription, ... -
Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression
Whitton, Laura; Cosgrove, Donna; Clarkson, Christopher; Harold, Denise; Kendall, Kimberley; Richards, Alex; Mantripragada, Kiran; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Hartmann, Annette; Konte, Betina; Rujescu, Dan; Gill, Michael; Corvin, Aiden; Rea, Stephen; Donohoe, Gary; Morris, Derek W. (Wiley, 2016-10-20)Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, and synaptic plasticity. These ... -
Deciphering the role of human MSL2 and MSL1 within and beyond the MSL complex
Meller, Anna (2018-01-14)While the components of the MSL (Male Specific Lethal) complex in Drosophila are well studied and known to play a critical role in dosage compensation, there is little known about the function of its evolutionary conserved ... -
Functional Analysis of Vertebrate Msl2
Lai, Zheng (2014-02-12)hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ... -
hMOF and associated proteins in transcription and cancer
Clasen, Sandra (2013-04-24)The lysine acetyltransferase MOF (males absent on the first) has been associated with transcriptional activation in Drosophila melanogaster. This activation is mediated by its acetylation of histone H4 at lysine 16 ... -
The lysine acetyltransferase MOF: its interactome, role in breast cancer, and characterisation of a novel isoform
Lane, Karen (2017-11-24)Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac), though it has also been shown to acetylate several ... -
Msl2 is a novel component of the vertebrate dna damage response
Lai, Zheng; Moravcová, Simona; Canitrot, Yvan; Andrzejewski, Lukasz P.; Walshe, Dervla M.; Rea, Stephen (Public Library of Science (PLoS), 2013-07-09)hMSL2 (male-specific lethal 2, human) is a RING finger protein with ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription regulation ...