Browsing by Author "Pandit, Abhay"
Now showing items 1-20 of 120
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A clinically relevant in vivo model for the assessment of scaffold efficacy in abdominal wall reconstruction
Chan, Jeffrey CY; Burugapalli, Krishna; Huang, Yi-Shiang; Kelly, John L; Pandit, Abhay (SAGE Publications, 2016-12-30)An animal model that allows for assessment of the degree of stretching or contraction of the implant area and the in vivo degradation properties of biological meshes is required to evaluate their performance in vivo. Adult ... -
A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling
Monaghan, Michael; Browne, Shane; Schenke-Layland, Katja; Pandit, Abhay (Elsevier BV, 2014-04-01)Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ... -
The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome
Rossi, Rosanna; Fitzgerald, Sean; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Santos, Andreia M. Silva; Murphy, Blathnaid; Alderson, Jack; Brennan, Paul; Power, Sarah; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, Andras; Vadasz, Agnes; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2020-09-16)Both intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatments for acute ischemic stroke (AIS) in selected cases. Recanalization may occur following IVT without the necessity of further ... -
Advanced functional polymers addressing the needs of modern medicine
Julich-Gruner, Konstanze K.; Pandit, Abhay; Lendlein, Andreas (Wiley-Blackwell, 2015-11-01) -
Amine functionalization of cholecyst-derived extracellular matrix with generation 1 pamam dendrimer
Chan, Jeffrey C. Y.; Burugapalli, Krishna; Naik, Hemantkumar; Kelly, John L.; Pandit, Abhay (American Chemical Society (ACS), 2008-02-01)A method to functionalize cholecyst-derived extracellular matrix (CEM) with free amine groups was established in an attempt to improve its potential for tethering of bioactive molecules. CEM was incorporated with Generation-1 ... -
Anti-Inflammatory Gene Therapy for the Promotion of Implanted Stem Cell Survival in Infarcted Myocardium
Holladay, Carolyn (2011-04-13)Cardiovascular disease is the leading cause of death in the developed world and is responsible for approximately 36% of Irish mortality. Myocardial infarction (MI), which is literally the death of cardiac tissue due to ... -
Artificial cornea: Past, current, and future directions
Holland, Gráinne; Pandit, Abhay; Sánchez-Abella, Laura; Haiek, Andrea; Loinaz, Iraida; Dupin, Damien; Gonzalez, Maria; Larra, Eva; Bidaguren, Aritz; Lagali, Neil; Moloney, Elizabeth B.; Ritter, Thomas (Frontiers Media, 2021-11-12)Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
Kraskiewicz, Honorata; Breen, Bridget; Sargeant, Timothy; McMahon, Siobhan; Pandit, Abhay (American Chemical Society (ACS), 2013-09-18)Neurotrophins, as important regulators of neural development, function, and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
Kraskiewicz, Honorata; Breen, Bridget; Sargeant, Timothy; McMahon, Siobhan; Pandit, Abhay (American Chemical Society, 2013-06-13)Neurotrophins, as important regulators of neural development, function and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
Abbah, Sunny; Spanoudes, Kyriakos; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I. (Springer Nature, 2014-01-01)Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional ... -
Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model
O’Loughlin, Aonghus; Kulkarni, Mangesh; Vaughan, Erin E; Creane, Michael; Liew, Aaron; Dockery, Peter; Pandit, Abhay; O’Brien, Timothy (Springer Nature, 2013-01-01)Introduction: Diabetic foot ulceration is the leading cause of amputation in people with diabetes mellitus. Peripheral vascular disease is present in the majority of patients with diabetic foot ulcers. Despite standard ... -
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties
Joyce, Kieran; Fabra, Georgina Targa; Bozkurt, Yagmur; Pandit, Abhay (Springer Nature, 2021-03-19)Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, ... -
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
Daly, William; Yao, Li; Zeugolis, Dimitrios I.; Pandit, Abhay (The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
Alexander, Jennifer C.; Browne, Shane; Pandit, Abhay; Rochev, Yury (Public Library of Science (PLoS), 2013-06-03)Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
Mathew, Asha (2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
Kotla, Niranjan (NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
A biomaterials approach to peripheral nerve repair
Daly, William (2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
Buttressing staples with cholecyst-derived extracellular matrix (cem) reinforces staple lines in an ex vivo peristaltic inflation model
Burugapalli, Krishna; Chan, Jeffrey C. Y.; Kelly, John L.; Pandit, Abhay (Springer Nature, 2008-05-06)Background Staple line leakage and bleeding are the most common problems associated with the use of surgical staplers for gastrointestinal resection and anastomotic procedures. These complications can be reduced by reinforcing ... -
Characterization of the ‘White’ appearing clots that cause acute ischemic stroke
Mereuta, Oana Madalina; Rossi, Rosanna; Douglas, Andrew; Molina Gil, Sara; Fitzgerald, Seán; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Eric; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; O'Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David F.; Szikora, Istvan; Rentzos, Alexandros; Tatlisumak, Turgut; Thornton, John; Doyle, Karen M. (Elsevier, 2021-09-28)Objectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the ... -
Characterizing nanoscale topography of the aortic heart valve basement membrane for tissue engineering heart valve scaffold design
Brody, Sarah; Anilkumar, Thapasimuthu; Liliensiek, Sara; Last, Julie A.; Murphy, Christopher J.; Pandit, Abhay (Mary Ann Liebert Inc, 2006-02-01)A fully effective prosthetic heart valve has not yet been developed. A successful tissue-engineered valve prosthetic must contain a scaffold that fully supports valve endothelial cell function. Recently, topographic features ...