Browsing by Author "Moureau, Sylvie"
Now showing items 1-4 of 4
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A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
Moureau, Sylvie; Luessing, Janna; Harte, Emma Christina; Voisin, Muriel; Lowndes, Noel Francis (The Royal Society, 2016-09-01)Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a ... -
Regulation and function of the tumour suppressor 53BP1 at sites of DNA damage
Moureau, Sylvie (2013-10-16)Cancer is the major cause of death for people in middle age. It results from cell transformation into malignant cells and propagates with normal controls. This process is induced by mutations occurring in DNA through the ... -
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
FitzGerald, Jennifer; Moureau, Sylvie; O'Connell, Enda; Grenon, Muriel; Muriel, Noel F. (PLoS, 2011-02)Background Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ... -
Regulation of the dna damage response and gene expression by the dot1l histone methyltransferase and the 53bp1 tumour suppressor
FitzGerald, Jennifer; Moureau, Sylvie; Drogaris, Paul; O'Connell, Enda; Abshiru, Nebiyu; Verreault, Alain; Thibault, Pierre; Grenon, Muriel; Lowndes, Noel F. (Public Library of Science (PLoS), 2011-02-24)Background: Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ...