Browsing by Author "Morrison, John J."
Now showing items 1-20 of 25
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Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
Lirussi, Fréderic; Rakotoniaina, Zo; Madani, Siham; Goirand, Françoise; Breuiller-Fouché, Michelle; Leroy, Marie-Josèphe; Sagot, Paul; Morrison, John J.; Dumas, Monique; Bardou, Marc (Oxford University Press (OUP), 2008-03-01)The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest ... -
Analysis of Maxi-K alpha subunit splice variants in human myometrium
Curley, Michael; Morrison, John J.; Smith, Terry (springer, 2004-09-21)Background: Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis. However, the regulatory mechanism(s) governing ... -
Cardiac troponin i in pre-eclampsia and gestational hypertension
Fleming, Sean M.; O'Gorman, Thomas; Finn, Joseph; Grimes, Helen; Daly, Kieran; Morrison, John J. (Wiley-Blackwell, 2000-11-01)Objective To investigate serum cardiac troponin I, a sensitive marker of cardiac myocyte damage, in normal pregnancy and pregnancies complicated by hypertension with and without significant proteinuria. Design Prospective ... -
Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure
Abou-Elwafa Abdallah, Mohamed; Wemken, Nina; Drage, Daniel Simon; Tlustos, Christina; Cellarius, Claire; Cleere, Kathy; Morrison, John J.; Daly, Sean; Coggins, Marie Ann; Harrad, Stuart (Elsevier, 2019-12-20)Concentrations of 10 perfluoroalkyl substances (PFASs) were measured in 16 pools of human milk from Ireland. Only four PFASs were detected (PFOA, PFNA, PFHxS and PFOS), with concentrations dominated by PFOA which was ... -
Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) in human milk from Ireland: temporal trends and implications for nursing infant exposure
Houlihan, Margarete; Wemken, Nina; Keogh, Myra; O’Riordain, Colman; Noone, Conor; Tierney, Julie; Claire Cellarius, Claire; Cleere, Kathy; Morrison, John J.; Daly, Sean; Harrad, Stuart; Tlustos, Christina; Coggins, Marie Ann (OAE Publishing Inc, 2021-11-19)Aim: The elucidation of temporal trends in human exposure to polychlorinated biphenyls (PCBs) and 17 polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) since the previous Irish human milk surveys and to evaluate the ... -
Definition of intertwin birth weight discordance
Breathnach, Fionnuala M.; McAuliffe, Fionnuala M.; Geary, Michael; Daly, Sean; Higgins, John R.; Dornan, James; Morrison, John J.; Burke, Gerard; Higgins, Shane; Dicker, Patrick; Manning, Fiona; Mahony, Rhona; Malone, Fergal D. (Ovid Technologies (Wolters Kluwer Health), 2011-07-01)OBJECTIVE: To establish the level of birth weight discordance at which perinatal morbidity increases in monochorionic and dichorionic twin pregnancy. METHODS: This prospective multicenter cohort study included 1,028 ... -
Differential expression of the metalloproteinase MMP3 and the a5 integrin subunit in human myometrium at labour
Ahamide, Elodie; Morrison, John J.; O Shaughnessy, Deirdre; O Brien, Margaret; Smith, Terry (Oxford University Press, 2007-09-13)Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ... -
Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Maharaj, Chrisen H.; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D.; Morrison, John J.; Laffey, John G. (2009)Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ... -
Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor1
O'Brien, Margaret; Morrison, John J.; Smith, Terry J. (Oxford University Press (OUP), 2008-01-01)As thrombin is proposed to be involved in stimulating myometrial contractility during labor and preterm labor, we aimed to investigate the expression of prothrombin (F7), the precursor of thrombin, its receptors, the ... -
Expression of RHOGTPase regulators in human myometrium
Mullins, Brian; O'Brien, Margaret; Flynn, David; Smith, Terry; Morrison, John J. (Reproductive Biology and Endocrinology, 2008-01-11)Background: RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), ... -
Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry; Morrison, John J. (Endocrine Society, 2005-07-02)Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ... -
Functional coupling of β3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes
Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry J.; Morrison, John J. (The Endocrine Society, 2005-10-01)Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K(+) channels (BK(Ca)) play a significant role in modulating cell membrane potential and ... -
Ghrelin in the human myometrium
O'Brien, Margaret; Earley, Padraig; Morrison, John J.; Smith, Terry (BioMed Central Ltd, 2010-03-29)Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ... -
Ghrelin in the human myometrium
Smith, Terry; O'Brien, Margaret; Morrison, John J. (2010)Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ... -
Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the bkcachannel
Doheny, Helen C.; Houlihan, Diarmaid D.; Ravikumar, Nandini; Smith, Terry J.; Morrison, John J. (The Endocrine Society, 2003-09-01)The uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are ... -
Human uterine lower segment myometrial cell and nuclear volume at term: influence of maternal age
Sweeney, Eva M.; Dockery, Peter; Crankshaw, Denis J.; O'Brien, Yvonne M.; Walsh, Jennifer M.; Morrison, John J. (Wiley-Blackwell, 2014-09-29)Little is known about the cytoarchitecture of human myometrial cells in pregnancy, and whether or not this may be influenced by maternal characteristics such as age, parity and body mass index (BMI). The aim of this study ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Morrison, John J.; Smith, Terry; O'Brien, Margaret; Fitzgibbon, Joan (Springer, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are ... -
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Fitzgibbon, Joan; Morrison, John J.; Smith, Terry; O'Brien, Margaret (BioMed Central, 2009-01-08)Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ... -
Optimum timing for planned delivery of uncomplicated monochorionic and dichorionic twin pregnancies
Breathnach, Fionnuala M.; McAuliffe, Fionnuala M.; Geary, Michael; Daly, Sean; Higgins, John R.; Dornan, James; Morrison, John J.; Burke, Gerard; Higgins, Shane; Dicker, Patrick; Manning, Fiona; Carroll, Stephen; Malone, Fergal D. (Ovid Technologies (Wolters Kluwer Health), 2012-01-01)OBJECTIVE: To determine the optimum timing for planned delivery of uncomplicated monochorionic and dichorionic twin pregnancies. METHODS: Unselected twin pregnancies were recruited for this prospective cohort study (N=1,028), ... -
Recreational drugs and fetal gastroschisis: maternal hair analysis in the peri-conceptional period and during pregnancy
Morrison, John J.; Chitty, Lynn S.; Peebles, Donald; Rodeck, Charles H. (Wiley-Blackwell, 2005-08-01)Objective To objectively measure individual recreational drug groups in maternal hair samples timed for the period of conception and different stages of pregnancy in expectant mothers with a diagnosis of fetal gastroschi ...